Abstract：
OBJECTIVE: Uveal melanoma is the most prevalent intraocular malignancy in adults, derived from uveal tract melanocytes. This study focuses on the frequency and risk of second primary malignancies in UM patients.
METHODS: A PubMed search (1980-2023) identified studies on SPM incidence in UM patients. From 191 references, 14 studies were chosen, focusing on UM, SPMs, and analysing data on demographics and types of neoplasms.
RESULTS: Among 31,235 UM patients in 14 studies, 4695 had 4730 SPMs (15.03% prevalence). Prostate (15%), breast (12%), and colorectal (9%) cancers were most common. Digestive system malignancies were highest (19%), with colorectal cancer leading (51%). Breast and prostate cancers were prevalent in respective systems. Lung, bladder, and non-Hodgkin\'s lymphoma were also notable. The study observed an increasing trend in the frequency of SPMs over time, reflecting broader trends in cancer survivorship and the growing prevalence of multiple malignancies.
CONCLUSIONS: The study highlights a significant presence of SPMs in UM patients, with an increasing trend in frequency over time, emphasizing prostate and breast cancers. This underscores the need for focused surveillance and tailored follow-up for UM survivors, considering their higher risk of additional malignancies. Future research should further investigate SPM aetiology in UM patients.
METHODS: A PubMed search (1980-2023) identified studies on SPM incidence in UM patients. From 191 references, 14 studies were chosen, focusing on UM, SPMs, and analysing data on demographics and types of neoplasms.
RESULTS: Among 31,235 UM patients in 14 studies, 4695 had 4730 SPMs (15.03% prevalence). Prostate (15%), breast (12%), and colorectal (9%) cancers were most common. Digestive system malignancies were highest (19%), with colorectal cancer leading (51%). Breast and prostate cancers were prevalent in respective systems. Lung, bladder, and non-Hodgkin\'s lymphoma were also notable. The study observed an increasing trend in the frequency of SPMs over time, reflecting broader trends in cancer survivorship and the growing prevalence of multiple malignancies.
CONCLUSIONS: The study highlights a significant presence of SPMs in UM patients, with an increasing trend in frequency over time, emphasizing prostate and breast cancers. This underscores the need for focused surveillance and tailored follow-up for UM survivors, considering their higher risk of additional malignancies. Future research should further investigate SPM aetiology in UM patients.
摘要：
目的：葡萄膜黑色素瘤是成人眼内最常见的恶性肿瘤，来源于葡萄膜黑素细胞。这项研究的重点是UM患者第二原发性恶性肿瘤的发生频率和风险。
方法：PubMed搜索（1980-2023）确定了UM患者SPM发生率的研究。从191个参考文献中，选择了14项研究，专注于UM，SPMs,并分析有关人口统计学和肿瘤类型的数据。
结果：在14项研究的31,235名UM患者中，4695例患者有4730例SPM（患病率15.03%）。前列腺（15%）乳房（12％），和大肠癌（9％）是最常见的。消化系统恶性肿瘤最高（19%），以结直肠癌为首（51%）。乳腺癌和前列腺癌在各自的系统中普遍存在。肺，膀胱,和非霍奇金淋巴瘤也值得注意。该研究观察到SPM的频率随着时间的推移而增加的趋势，反映了癌症生存率的更广泛趋势和多种恶性肿瘤患病率的增加。
结论：该研究强调了UM患者中明显存在SPM，随着时间的推移，频率有增加的趋势，强调前列腺癌和乳腺癌。这强调了对UM幸存者进行重点监测和量身定制的后续行动的必要性，考虑到他们患其他恶性肿瘤的风险较高。未来的研究应进一步研究UM患者的SPM病因。
方法：PubMed搜索（1980-2023）确定了UM患者SPM发生率的研究。从191个参考文献中，选择了14项研究，专注于UM，SPMs,并分析有关人口统计学和肿瘤类型的数据。
结果：在14项研究的31,235名UM患者中，4695例患者有4730例SPM（患病率15.03%）。前列腺（15%）乳房（12％），和大肠癌（9％）是最常见的。消化系统恶性肿瘤最高（19%），以结直肠癌为首（51%）。乳腺癌和前列腺癌在各自的系统中普遍存在。肺，膀胱,和非霍奇金淋巴瘤也值得注意。该研究观察到SPM的频率随着时间的推移而增加的趋势，反映了癌症生存率的更广泛趋势和多种恶性肿瘤患病率的增加。
结论：该研究强调了UM患者中明显存在SPM，随着时间的推移，频率有增加的趋势，强调前列腺癌和乳腺癌。这强调了对UM幸存者进行重点监测和量身定制的后续行动的必要性，考虑到他们患其他恶性肿瘤的风险较高。未来的研究应进一步研究UM患者的SPM病因。
