%0 Systematic Review
%T Multiple neoplasms in patients with uveal melanoma: a systematic review.
%A de Esteban Maciñeira E
%A Fernández Fernández P
%A Conde González I
%A Bande Rodríguez MF
%A Blanco Teijeiro MJ
%J Int Ophthalmol
%V 44
%N 1
%D 2024 Jun 22
%M 38909111
%F 2.029
%R 10.1007/s10792-024-03164-z
%X <B>OBJECTIVE: </B>Uveal melanoma is the most prevalent intraocular malignancy in adults, derived from uveal tract melanocytes. This study focuses on the frequency and risk of second primary malignancies in UM patients.<BR><B>METHODS: </B>A PubMed search (1980-2023) identified studies on SPM incidence in UM patients. From 191 references, 14 studies were chosen, focusing on UM, SPMs, and analysing data on demographics and types of neoplasms.<BR><B>RESULTS: </B>Among 31,235 UM patients in 14 studies, 4695 had 4730 SPMs (15.03% prevalence). Prostate (15%), breast (12%), and colorectal (9%) cancers were most common. Digestive system malignancies were highest (19%), with colorectal cancer leading (51%). Breast and prostate cancers were prevalent in respective systems. Lung, bladder, and non-Hodgkin's lymphoma were also notable. The study observed an increasing trend in the frequency of SPMs over time, reflecting broader trends in cancer survivorship and the growing prevalence of multiple malignancies.<BR><B>CONCLUSIONS: </B>The study highlights a significant presence of SPMs in UM patients, with an increasing trend in frequency over time, emphasizing prostate and breast cancers. This underscores the need for focused surveillance and tailored follow-up for UM survivors, considering their higher risk of additional malignancies. Future research should further investigate SPM aetiology in UM patients.