PDF(Pubmed)
Abstract：
BACKGROUND: Spinal tuberculosis (STB) is a local manifestation of systemic infection caused by Mycobacterium tuberculosis, accounting for a significant proportion of joint tuberculosis cases. This study aimed to explore the diagnostic value of MRI combined with mannose-binding lectin (MBL) for STB.
METHODS: 124 patients suspected of having STB were collected and divided into STB and non-STB groups according to their pathological diagnosis. Serum MBL levels were measured using ELISA and a Pearson analysis was constructed to determine the correlation between MBL and STB. ROC was plotted to analyze their diagnostic value for STB. All the subjects included in the study underwent an MRI.
RESULTS: The sensitivity of MRI for the diagnosis of STB was 84.38% and specificity was 86.67%. The serum MBL levels of the patients in the STB group were significantly lower than the levels in the non-STB group. ROC analysis results indicated that serum MBL\'s area under the curve (AUC) for diagnosis of STB was 0.836, with a sensitivity of 82.3% and a specificity was 77.4%. The sensitivity of MRI combined with MBL diagnosis was 96.61%, and the specificity was 92.31%, indicating that combining the two diagnostic methods was more effective than using either one alone.
CONCLUSIONS: Both MRI and MBL had certain diagnostic values for STB, but their combined use resulted in a diagnostic accuracy than either one alone.
METHODS: 124 patients suspected of having STB were collected and divided into STB and non-STB groups according to their pathological diagnosis. Serum MBL levels were measured using ELISA and a Pearson analysis was constructed to determine the correlation between MBL and STB. ROC was plotted to analyze their diagnostic value for STB. All the subjects included in the study underwent an MRI.
RESULTS: The sensitivity of MRI for the diagnosis of STB was 84.38% and specificity was 86.67%. The serum MBL levels of the patients in the STB group were significantly lower than the levels in the non-STB group. ROC analysis results indicated that serum MBL\'s area under the curve (AUC) for diagnosis of STB was 0.836, with a sensitivity of 82.3% and a specificity was 77.4%. The sensitivity of MRI combined with MBL diagnosis was 96.61%, and the specificity was 92.31%, indicating that combining the two diagnostic methods was more effective than using either one alone.
CONCLUSIONS: Both MRI and MBL had certain diagnostic values for STB, but their combined use resulted in a diagnostic accuracy than either one alone.
摘要：
背景：脊柱结核（STB）是由结核分枝杆菌引起的全身感染的局部表现，占关节结核病例的很大比例。本研究旨在探讨MRI联合甘露糖结合凝集素(MBL)对STB的诊断价值。
方法：收集124例疑似STB患者，根据病理诊断分为STB组和非STB组。使用ELISA测量血清MBL水平，并构建Pearson分析以确定MBL和STB之间的相关性。绘制ROC以分析其对STB的诊断价值。研究中包括的所有受试者均接受MRI检查。
结果：MRI诊断STB的敏感性为84.38%，特异性为86.67%。STB组患者血清MBL水平明显低于非STB组。ROC分析结果表明，血清MBL/曲线下面积（AUC）诊断STB为0.836，敏感性为82.3％，特异性为77.4％。MRI联合MBL诊断的敏感性为96.61%。特异性为92.31%,这表明联合两种诊断方法比单独使用任何一种方法更有效.
结论：MRI和MBL对STB均有一定的诊断价值，但是它们的联合使用导致了比任何一个单独的诊断准确性。
方法：收集124例疑似STB患者，根据病理诊断分为STB组和非STB组。使用ELISA测量血清MBL水平，并构建Pearson分析以确定MBL和STB之间的相关性。绘制ROC以分析其对STB的诊断价值。研究中包括的所有受试者均接受MRI检查。
结果：MRI诊断STB的敏感性为84.38%，特异性为86.67%。STB组患者血清MBL水平明显低于非STB组。ROC分析结果表明，血清MBL/曲线下面积（AUC）诊断STB为0.836，敏感性为82.3％，特异性为77.4％。MRI联合MBL诊断的敏感性为96.61%。特异性为92.31%,这表明联合两种诊断方法比单独使用任何一种方法更有效.
结论：MRI和MBL对STB均有一定的诊断价值，但是它们的联合使用导致了比任何一个单独的诊断准确性。
