METHODS: A smartphone-based self-management platform, offering remote PRO measurement for PD patients, has been developed. A total of 1828 PD patients, including 1001 male patients and 827 female patients, were enrolled and completed their PRO submission through this platform.
RESULTS: Sex differences in PROs have been identified. The female group had a significantly lower height, weight, and body mass index (BMI) than the male group (P < 0.001). For motor symptoms, a higher proportion of patients reporting dyskinesia was observed in the female group. For non-motor symptoms, there is a higher percentage (P < 0.001) as well as severity (P = 0.016) of depression in the female group. More male patients reported hyposmia, lisp, drooling, dysuria, frequent urination, hypersexuality, impotence, daytime sleepiness, and apathy than females (P < 0.05). In contrast, more female patients reported headache, palpation, body pain, anorexia, nausea, urinal incontinence, anxiety, insomnia (P < 0.05) than males.
CONCLUSIONS: We provide evidence for sex differences in PD through the data collected from our platform. These results highlighted the importance of gender in clinical decision-making, and also support the feasibility of remote PRO measurement through a smartphone-based self-management platform in patients with PD.
方法:基于智能手机的自我管理平台,为PD患者提供远程PRO测量,已经开发了。共有1828名PD患者,包括1001名男性患者和827名女性患者,通过这个平台注册并完成了他们的PRO提交。
结果:已经确定了PRO的性别差异。女性组的身高明显较低,体重,体重指数(BMI)高于男性组(P<0.001)。对于运动症状,女性组报告运动障碍的患者比例较高.对于非运动症状,女性组的抑郁症发生率(P<0.001)和严重程度(P=0.016)均较高。更多的男性患者报告说,lisp,流口水,排尿困难,尿频,性欲亢进,阳痿,白天嗜睡,且冷漠高于女性(P<0.05)。相比之下,更多的女性患者报告头痛,触诊,身体疼痛,厌食症,恶心,小便失禁,焦虑,失眠(P<0.05)高于男性。
结论:我们通过从我们的平台收集的数据提供了PD性别差异的证据。这些结果强调了性别在临床决策中的重要性,并且还支持通过基于智能手机的自我管理平台对PD患者进行远程PRO测量的可行性。