Abstract：
OBJECTIVE: To explore multiple features of attention impairments in patients with temporal lobe epilepsy (TLE).
METHODS: A total of 93 patients diagnosed with TLE at Xiangya Hospital during May 2022 and December 2022 and 85 healthy controls were included in this study. Participants were asked to complete neuropsychological scales and attention network test (ANT) with recording of eye-tracking and electroencephalogram.
RESULTS: All means of evaluation showed impaired attention functions in TLE patients. ANT results showed impaired orienting (p < 0.001) and executive control (p = 0.041) networks. Longer mean first saccade time (p = 0.046) and more total saccadic counts (p = 0.035) were found in eye-tracking results, indicating abnormal alerting and orienting networks. Both alerting, orienting and executive control networks were abnormal, manifesting as decreased amplitudes (N1 & P3, p < 0.001) and extended latency (P3, p = 0.002). The energy of theta, alpha and beta were all sensitive to the changes of alerting and executive control network with time, but only beta power was sensitive to the changes of orienting network.
CONCLUSIONS: Our findings are helpful for early identification of patients with TLE combined with attention impairments, which have strong clinical guiding significance for long-term monitoring and intervention.
METHODS: A total of 93 patients diagnosed with TLE at Xiangya Hospital during May 2022 and December 2022 and 85 healthy controls were included in this study. Participants were asked to complete neuropsychological scales and attention network test (ANT) with recording of eye-tracking and electroencephalogram.
RESULTS: All means of evaluation showed impaired attention functions in TLE patients. ANT results showed impaired orienting (p < 0.001) and executive control (p = 0.041) networks. Longer mean first saccade time (p = 0.046) and more total saccadic counts (p = 0.035) were found in eye-tracking results, indicating abnormal alerting and orienting networks. Both alerting, orienting and executive control networks were abnormal, manifesting as decreased amplitudes (N1 & P3, p < 0.001) and extended latency (P3, p = 0.002). The energy of theta, alpha and beta were all sensitive to the changes of alerting and executive control network with time, but only beta power was sensitive to the changes of orienting network.
CONCLUSIONS: Our findings are helpful for early identification of patients with TLE combined with attention impairments, which have strong clinical guiding significance for long-term monitoring and intervention.
摘要：
目的：探讨颞叶癫痫（TLE）患者注意障碍的多重特征。
方法：选取2022年5月至2022年12月湘雅医院诊断为TLE的93例患者和85名健康对照者作为研究对象。要求参与者完成神经心理学量表和注意力网络测试（ANT），并记录眼动和脑电图。
结果：所有评估方法均显示TLE患者的注意力功能受损。ANT结果显示定向(p<0.001)和执行控制(p=0.041)网络受损。在眼球追踪结果中发现了更长的平均第一次扫视时间（p=0.046）和更多的总扫视计数（p=0.035）。指示异常警报和定向网络。两者都在警觉，定向和执行控制网络异常，表现为振幅降低（N1和P3，p<0.001）和潜伏期延长（P3，p=0.002）。θ的能量，α和β都对警报和执行控制网络随时间的变化敏感，但是只有贝塔力量对定向网络的变化很敏感。
结论：我们的发现有助于早期识别合并注意力障碍的TLE患者，对长期监测和干预具有较强的临床指导意义。
方法：选取2022年5月至2022年12月湘雅医院诊断为TLE的93例患者和85名健康对照者作为研究对象。要求参与者完成神经心理学量表和注意力网络测试（ANT），并记录眼动和脑电图。
结果：所有评估方法均显示TLE患者的注意力功能受损。ANT结果显示定向(p<0.001)和执行控制(p=0.041)网络受损。在眼球追踪结果中发现了更长的平均第一次扫视时间（p=0.046）和更多的总扫视计数（p=0.035）。指示异常警报和定向网络。两者都在警觉，定向和执行控制网络异常，表现为振幅降低（N1和P3，p<0.001）和潜伏期延长（P3，p=0.002）。θ的能量，α和β都对警报和执行控制网络随时间的变化敏感，但是只有贝塔力量对定向网络的变化很敏感。
结论：我们的发现有助于早期识别合并注意力障碍的TLE患者，对长期监测和干预具有较强的临床指导意义。
