Abstract：
This article traces the career of Dr. Sabina Luchetti (1969-2021), a noted physician (medical doctor, specialized in Neurology at Tor Vergata University of Rome, Italy), a dedicated neuroscientist (Ph.D. in Neuroscience at Tor Vergata University and IRCCS Santa Lucia of Rome), and a member of a renowned Netherlands group (senior researcher at Professor Swaab Laboratory of the Netherlands Institute for Neuroscience, Amsterdam, Netherlands), working in the field of brain function and diseases. She is particularly involved in the study of natural compounds, such as neurosteroids and their biosynthetic pathways in neurodegenerative and neuroinflammation- related disorders, working on post-mortem human brains. This editorial outlines Dr. Luchetti\'s wide range of interests, discloses her superior fund of knowledge, and recollects her humanitarian spirit, all of which contribute to creating a great sense of belonging to any group of researchers whom she worked with. The impact of Dr. Luchetti\'s work will continue to be felt for many years. From the bench to the bedside, her work has indirectly contributed to shedding light on the neurosteroids\' potential therapeutic effects, considering that neurosteroids and their analogues (some of which are over-the-counter) are now used to treat depression, epilepsy, and substance abuse disorders. Moreover, the potential therapeutic effects of allopregnanolone with respect to its capability to promote neuroregeneration and neuroprotection are a promising basis for future treatment of neurodegenerative diseases.
摘要：
这篇文章追溯了SabinaLuchetti博士（1969-2021）的职业生涯，著名的医生(医生，罗马TorVergata大学神经学专业，意大利),一位专门的神经科学家（TorVergata大学神经科学博士学位和罗马的IRCCSSantaLucia），和荷兰著名小组的成员（荷兰神经科学研究所Swaab教授实验室的高级研究员，阿姆斯特丹,荷兰),在脑功能和疾病领域工作。她特别参与天然化合物的研究，如神经类固醇及其在神经退行性疾病和神经炎症相关疾病中的生物合成途径，研究死后人类的大脑.这篇社论概述了卢切蒂博士的广泛兴趣，披露了她优越的知识基金，回忆她的人道主义精神，所有这些都有助于创造一种与她一起工作的任何一组研究人员的归属感。Luchetti博士工作的影响将持续多年。从长凳到床边，她的工作间接有助于揭示神经类固醇的潜在治疗效果，考虑到神经类固醇及其类似物（其中一些是非处方药）现在被用于治疗抑郁症，癫痫,和药物滥用障碍。此外，别孕烯醇酮在促进神经再生和神经保护方面的潜在治疗作用是未来治疗神经退行性疾病的有希望的基础。
