PDF(Pubmed)
Abstract：
UNASSIGNED: The margin status of oral squamous cell carcinoma patients is considered to be predictive of recurrence and long-term survival. Therefore, precise intraoperative margin assessment is crucial. This study investigated the feasibility of using near-infrared fluorescence imaging technology to guide margin design in oral squamous cell carcinoma patients.
UNASSIGNED: In this retrospective study, indocyanine green solution was intravenously injected preoperatively into patients. Intraoperatively, the surgical area was illuminated using a near-infrared fluorescence imaging system, which caused the lesion to fluoresce in the surgical area. Surgery was performed with the assistance of fluorescence imaging. The fluorescence intensity of the lesion area and surrounding normal tissue was recorded during surgery. Intraoperative margins were sent for rapid pathology, and postoperative margin pathology results were documented.
UNASSIGNED: Sixteen patients were included in this study (7 males, 9 females), with an average age of 65.65 ± 12.37 years. Preoperative biopsy and postoperative pathology confirmed oral squamous cell carcinoma in all patients. No cancer cells were found in the margin pathology results. The average fluorescence intensity of the lesion area was 214 ± 4.70, and that of the surrounding normal tissue was 104.63 ± 3.14. There was no significant difference in the fluorescence intensity values of the lesion areas among all patients (F=0.38, P>0.05). There was a significant difference in fluorescence intensity between the lesion area and surrounding normal tissue (t=33.76, P<0.05).
UNASSIGNED: Near-infrared fluorescence imaging technology can aid in real-time imaging differentiation of lesion areas based on differences in fluorescence intensity during surgery. The use of this technology can assist surgeons in assessing the safety margin and reliably guide surgery.
UNASSIGNED: In this retrospective study, indocyanine green solution was intravenously injected preoperatively into patients. Intraoperatively, the surgical area was illuminated using a near-infrared fluorescence imaging system, which caused the lesion to fluoresce in the surgical area. Surgery was performed with the assistance of fluorescence imaging. The fluorescence intensity of the lesion area and surrounding normal tissue was recorded during surgery. Intraoperative margins were sent for rapid pathology, and postoperative margin pathology results were documented.
UNASSIGNED: Sixteen patients were included in this study (7 males, 9 females), with an average age of 65.65 ± 12.37 years. Preoperative biopsy and postoperative pathology confirmed oral squamous cell carcinoma in all patients. No cancer cells were found in the margin pathology results. The average fluorescence intensity of the lesion area was 214 ± 4.70, and that of the surrounding normal tissue was 104.63 ± 3.14. There was no significant difference in the fluorescence intensity values of the lesion areas among all patients (F=0.38, P>0.05). There was a significant difference in fluorescence intensity between the lesion area and surrounding normal tissue (t=33.76, P<0.05).
UNASSIGNED: Near-infrared fluorescence imaging technology can aid in real-time imaging differentiation of lesion areas based on differences in fluorescence intensity during surgery. The use of this technology can assist surgeons in assessing the safety margin and reliably guide surgery.
摘要：
■口腔鳞状细胞癌患者的边缘状态被认为是复发和长期生存的预测因素。因此,精确的术中切缘评估至关重要.本研究探讨应用近红外荧光成像技术指导口腔鳞状细胞癌患者切缘设计的可行性。
■在这项回顾性研究中，术前静脉注射吲哚菁绿溶液。术中,手术区域使用近红外荧光成像系统进行照明，导致病变在手术区域发出荧光。在荧光成像的辅助下进行手术。在手术过程中记录病变区域和周围正常组织的荧光强度。术中切缘被送去快速病理检查，记录术后切缘病理结果。
■本研究包括16名患者（7名男性，9名女性），平均年龄65.65±12.37岁。术前活检及术后病理均证实口腔鳞状细胞癌。切缘病理结果未见癌细胞。病变区的平均荧光强度为214±4.70，周围正常组织的平均荧光强度为104.63±3.14。所有患者病灶区荧光强度值差异无统计学意义(F=0.38,P>0.05)。病变区与周围正常组织的荧光强度差异有统计学意义(t=33.76,P<0.05)。
■近红外荧光成像技术可以根据手术过程中荧光强度的差异，帮助实时成像区分病变区域。该技术的使用可以帮助外科医生评估安全裕度并可靠地指导手术。
■在这项回顾性研究中，术前静脉注射吲哚菁绿溶液。术中,手术区域使用近红外荧光成像系统进行照明，导致病变在手术区域发出荧光。在荧光成像的辅助下进行手术。在手术过程中记录病变区域和周围正常组织的荧光强度。术中切缘被送去快速病理检查，记录术后切缘病理结果。
■本研究包括16名患者（7名男性，9名女性），平均年龄65.65±12.37岁。术前活检及术后病理均证实口腔鳞状细胞癌。切缘病理结果未见癌细胞。病变区的平均荧光强度为214±4.70，周围正常组织的平均荧光强度为104.63±3.14。所有患者病灶区荧光强度值差异无统计学意义(F=0.38,P>0.05)。病变区与周围正常组织的荧光强度差异有统计学意义(t=33.76,P<0.05)。
■近红外荧光成像技术可以根据手术过程中荧光强度的差异，帮助实时成像区分病变区域。该技术的使用可以帮助外科医生评估安全裕度并可靠地指导手术。
