■患有下肢动脉疾病(LEAD)的患者通常需要进行血运重建手术。目前使用的诊断方法不足以预测成功的结果,并且专注于大血管而不是微血管状态。几种提高诊断准确性的有希望的方式正在出现,包括最大收缩加速度(ACCmax),通过双工超声(DUS)测量。为了评估组织灌注,使用吲哚菁绿(ICG)的近红外荧光(NIR)成像显示了有希望的结果。本研究旨在确定将这两种方法结合用于大血管和微血管灌注评估以预测成功的临床结果的有用性。
■进行了一项回顾性研究,收集了接受血运重建的LEAD患者的介入前和介入后DUS和ICGNIR荧光成像测量值。介入前和介入后灌注参数之间的相关性,描述为δ(Δ)ACCmax和ΔICGNIR荧光参数,进行了分析。灌注参数的改善与临床结果相比,定义为无痛步行距离的改善,从休息的痛苦自由,或倾向于伤口和溃疡愈合。
■共纳入38例患者(42条肢体)。血管重建后ACCmax和ICGNIR荧光灌注参数显著改善(p<0.001)。临床结果差的患者在血运重建后两个参数的改善均显著降低(p<0.001-0.016)。在ACCmax和ICGNIR荧光成像之间发现缺乏相关性。在患者中观察到大血管参数(ACCmax)和灌注(ICGNIR荧光)的多种非一致改善。然而,对于所有临床结果成功的患者,至少一个参数得到改善。
■结合ACCmax和ICGNIR荧光成像显示在具有成功临床结果的所有患者中至少一个参数的改善。这项研究强调了评估下肢血管重建术后大血管状态和组织灌注的潜力,因为两者似乎都反映了血管化的不同方面。
结论:已经开发了许多技术来评估组织灌注,以预测外周动脉疾病患者血运重建后的临床结果。然而,没有一个在临床实践中广泛实施。这项研究强调了从不同角度采用多种模式进行更准确预测的重要性。通过关注大血管状态和组织灌注,临床医生可以更好地指导自己的治疗策略。
UNASSIGNED: Patients with lower extremity arterial disease (LEAD) frequently require revascularization procedures. Currently used diagnostic methods are insufficient in predicting successful outcomes and focus on macrovascular rather than microvascular state. Several promising modalities to increase diagnostic accuracy are emerging, including maximal systolic acceleration (ACCmax), measured by duplex ultrasound (DUS). For the assessment of tissue perfusion, near-infrared fluorescence (NIR) imaging using indocyanine green (ICG) demonstrates promising results. This study aims to identify the usefulness of combining these two methods for macrovascular and microvascular perfusion assessment to predict successful clinical outcomes.
UNASSIGNED: A retrospective study was performed collecting preinterventional and postinterventional DUS and ICG NIR fluorescence imaging measurements from LEAD patients undergoing revascularization. The correlation between the preinterventional and postinterventional perfusion parameters, described as the delta (Δ) ACCmax and ΔICG NIR fluorescence parameters, were analyzed. Improvements in perfusion parameters were compared to clinical outcomes, defined as improvement in pain-free walking distance, freedom from rest pain, or tendency toward wound and ulcer healing.
UNASSIGNED: A total of 38 patients (42 limbs) were included. ACCmax and ICG NIR fluorescence perfusion parameters improved significantly after revascularization (p<0.001). Patients with a poor clinical outcome had a significantly lower improvement of both parameters after revascularization (p<0.001-0.016). Lack of correlation was found between the delta of ACCmax and ICG NIR fluorescence imaging. Multiple non-congruent improvements of macrovascular parameters (ACCmax) and perfusion (ICG NIR fluorescence) were seen within patients. However, for all patients with a successful clinical outcome, at least one parameter improved.
UNASSIGNED: Combining ACCmax and ICG NIR fluorescence imaging revealed improvement in at least one parameter within all patients with a successful clinical outcome. This study highlights the potential of assessing both the macrovascular state and tissue perfusion following lower extremity revascularization, as both appear to reflect different aspects of vascularization.
CONCLUSIONS: Numerous techniques have been developed to assess tissue perfusion to predict clinical outcomes following revascularization in patients with peripheral artery disease. However, none are widely implemented in clinical practice. This study emphasized the importance of employing multiple modalities from different perspectives for more accurate prediction. By focusing on both the macrovascular state and tissue perfusion, clinicians can better guide themselves in their treatment strategies.