PDF(Pubmed)
Abstract：
UNASSIGNED: The human stress response is characterized by increases in neuromodulators, including norepinephrine (NE) and cortisol. Both neuromodulators can enter the brain and affect neurofunctional responses. Two brain areas associated with stress are the amygdala and the hippocampus. The precise influence of NE and cortisol on the amygdala and hippocampal resting state functional connectivity (RSFC) is poorly understood.
UNASSIGNED: To investigate the influence of NE and cortisol on the amygdala and hippocampal RSFC.
UNASSIGNED: We recruited 165 participants who received 10 mg yohimbine and/or 10 mg hydrocortisone in a randomized, placebo-controlled design. With seed-based analyses, we compared RSFC of the hippocampus and amygdala separately between the three groups that received medication versus placebo.
UNASSIGNED: We found no differences between yohimbine and placebo condition or between hydrocortisone and placebo condition regarding amygdala or hippocampal FC. Compared with placebo, the yohimbine/hydrocortisone condition showed increased amygdala and hippocampal RSFC with the cerebellum. Also, they had increased hippocampal RSFC with the amygdala and cerebral white matter.
UNASSIGNED: The group with elevated NE and cortisol showed significantly increased RSFC between the amygdala, hippocampus, and cerebellum compared to placebo. These three brain areas are involved in associative learning and emotional memory, suggesting a critical role for this network in the human stress response. Our results show that NE and cortisol together may influence the strength of this association. Compared to placebo, we found no differences in the groups receiving only one medication, suggesting that increasing one neuromodulator alone may not induce differences in neurofunctional responses. The study procedure has been registered at clinicaltrials.gov (ID: NCT04359147).
UNASSIGNED: To investigate the influence of NE and cortisol on the amygdala and hippocampal RSFC.
UNASSIGNED: We recruited 165 participants who received 10 mg yohimbine and/or 10 mg hydrocortisone in a randomized, placebo-controlled design. With seed-based analyses, we compared RSFC of the hippocampus and amygdala separately between the three groups that received medication versus placebo.
UNASSIGNED: We found no differences between yohimbine and placebo condition or between hydrocortisone and placebo condition regarding amygdala or hippocampal FC. Compared with placebo, the yohimbine/hydrocortisone condition showed increased amygdala and hippocampal RSFC with the cerebellum. Also, they had increased hippocampal RSFC with the amygdala and cerebral white matter.
UNASSIGNED: The group with elevated NE and cortisol showed significantly increased RSFC between the amygdala, hippocampus, and cerebellum compared to placebo. These three brain areas are involved in associative learning and emotional memory, suggesting a critical role for this network in the human stress response. Our results show that NE and cortisol together may influence the strength of this association. Compared to placebo, we found no differences in the groups receiving only one medication, suggesting that increasing one neuromodulator alone may not induce differences in neurofunctional responses. The study procedure has been registered at clinicaltrials.gov (ID: NCT04359147).
摘要：
■人类应激反应的特征是神经调质的增加，包括去甲肾上腺素（NE）和皮质醇。两种神经调质都可以进入大脑并影响神经功能反应。与压力相关的两个大脑区域是杏仁核和海马。NE和皮质醇对杏仁核和海马静息状态功能连接（RSFC）的确切影响知之甚少。
■研究NE和皮质醇对杏仁核和海马RSFC的影响。
■我们招募了165名参与者，他们随机接受了10毫克育亨宾和/或10毫克氢化可的松，安慰剂对照设计。通过基于种子的分析，我们分别比较了接受药物治疗和安慰剂治疗的三组海马体和杏仁核的RSFC.
■我们发现育亨宾和安慰剂条件之间或氢化可的松和安慰剂条件之间在杏仁核或海马FC方面没有差异。与安慰剂相比，育亨宾/氢化可的松情况显示杏仁核和海马RSFC随小脑增加。此外，他们增加了海马RSFC与杏仁核和大脑白质。
■NE和皮质醇升高的组显示杏仁核之间的RSFC显着增加，海马体,和小脑与安慰剂相比。这三个大脑区域参与联想学习和情绪记忆，表明该网络在人类应激反应中的关键作用。我们的结果表明，NE和皮质醇一起可能会影响这种关联的强度。与安慰剂相比，我们发现仅接受一种药物的组没有差异，表明单独增加一种神经调质可能不会引起神经功能反应的差异。该研究程序已在clinicaltrials.gov（ID：NCT04359147）上注册。
■研究NE和皮质醇对杏仁核和海马RSFC的影响。
■我们招募了165名参与者，他们随机接受了10毫克育亨宾和/或10毫克氢化可的松，安慰剂对照设计。通过基于种子的分析，我们分别比较了接受药物治疗和安慰剂治疗的三组海马体和杏仁核的RSFC.
■我们发现育亨宾和安慰剂条件之间或氢化可的松和安慰剂条件之间在杏仁核或海马FC方面没有差异。与安慰剂相比，育亨宾/氢化可的松情况显示杏仁核和海马RSFC随小脑增加。此外，他们增加了海马RSFC与杏仁核和大脑白质。
■NE和皮质醇升高的组显示杏仁核之间的RSFC显着增加，海马体,和小脑与安慰剂相比。这三个大脑区域参与联想学习和情绪记忆，表明该网络在人类应激反应中的关键作用。我们的结果表明，NE和皮质醇一起可能会影响这种关联的强度。与安慰剂相比，我们发现仅接受一种药物的组没有差异，表明单独增加一种神经调质可能不会引起神经功能反应的差异。该研究程序已在clinicaltrials.gov（ID：NCT04359147）上注册。
