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Abstract：
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne zoonosis caused by the SFTS virus (SFTSV). Understanding the prevalence of SFTSV RNA in humans, vertebrate hosts and ticks is crucial for SFTS control.
METHODS: A systematic review and meta-analysis were conducted to determine the prevalence of SFTSV RNA in humans, vertebrate hosts and questing ticks. Nine electronic databases were searched for relevant publications, and data on SFTSV RNA prevalence were extracted. Pooled prevalence was estimated using a random effects model. Subgroup analysis and multivariable meta-regression were performed to investigate sources of heterogeneity.
RESULTS: The pooled prevalence of SFTSV RNA in humans was 5.59% (95% confidence interval [CI] 2.78-9.15%) in those in close contact (close contacts) with infected individuals (infected cases) and 0.05% (95% CI 0.00-0.65%) in healthy individuals in endemic areas. The SFTSV infection rates in artiodactyls (5.60%; 95% CI 2.95-8.96%) and carnivores (6.34%; 95% CI 3.27-10.23%) were higher than those in rodents (0.45%; 95% CI 0.00-1.50%). Other animals, such as rabbits, hedgehogs and birds, also played significant roles in SFTSV transmission. The genus Haemaphysalis was the primary transmission vector, with members of Ixodes, Dermacentor, and Amblyomma also identified as potential vectors. The highest pooled prevalence was observed in adult ticks (1.03%; 95% CI 0.35-1.96%), followed by nymphs (0.66%; 95% CI 0.11-1.50%) and larvae (0.01%; 95% CI 0.00-0.46%). The pooled prevalence in ticks collected from endemic areas (1.86%; 95% CI 0.86-3.14%) was higher than that in ticks collected in other regions (0.41%; 95% CI 0.12-0.81%).
CONCLUSIONS: Latent SFTSV infections are present in healthy individuals residing in endemic areas, and close contacts with SFTS cases are at a significantly higher risk of infection. The type of animal is linked to infection rates in vertebrate hosts, while infection rates in ticks are associated with the developmental stage. Further research is needed to investigate the impact of various environmental factors on SFTSV prevalence in vertebrate hosts and ticks.
METHODS: A systematic review and meta-analysis were conducted to determine the prevalence of SFTSV RNA in humans, vertebrate hosts and questing ticks. Nine electronic databases were searched for relevant publications, and data on SFTSV RNA prevalence were extracted. Pooled prevalence was estimated using a random effects model. Subgroup analysis and multivariable meta-regression were performed to investigate sources of heterogeneity.
RESULTS: The pooled prevalence of SFTSV RNA in humans was 5.59% (95% confidence interval [CI] 2.78-9.15%) in those in close contact (close contacts) with infected individuals (infected cases) and 0.05% (95% CI 0.00-0.65%) in healthy individuals in endemic areas. The SFTSV infection rates in artiodactyls (5.60%; 95% CI 2.95-8.96%) and carnivores (6.34%; 95% CI 3.27-10.23%) were higher than those in rodents (0.45%; 95% CI 0.00-1.50%). Other animals, such as rabbits, hedgehogs and birds, also played significant roles in SFTSV transmission. The genus Haemaphysalis was the primary transmission vector, with members of Ixodes, Dermacentor, and Amblyomma also identified as potential vectors. The highest pooled prevalence was observed in adult ticks (1.03%; 95% CI 0.35-1.96%), followed by nymphs (0.66%; 95% CI 0.11-1.50%) and larvae (0.01%; 95% CI 0.00-0.46%). The pooled prevalence in ticks collected from endemic areas (1.86%; 95% CI 0.86-3.14%) was higher than that in ticks collected in other regions (0.41%; 95% CI 0.12-0.81%).
CONCLUSIONS: Latent SFTSV infections are present in healthy individuals residing in endemic areas, and close contacts with SFTS cases are at a significantly higher risk of infection. The type of animal is linked to infection rates in vertebrate hosts, while infection rates in ticks are associated with the developmental stage. Further research is needed to investigate the impact of various environmental factors on SFTSV prevalence in vertebrate hosts and ticks.
摘要：
背景：严重发热伴血小板减少综合征（SFTS）是由SFTS病毒（SFTSV）引起的一种新兴的蜱传人畜共患病。了解SFTSVRNA在人类中的流行，脊椎动物宿主和蜱对SFTS的控制至关重要。
方法：进行了系统综述和荟萃分析，以确定SFTSVRNA在人类中的患病率，脊椎动物寄主和寻找蜱。检索了九个电子数据库,寻找有关出版物,并提取SFTSVRNA流行数据。使用随机效应模型估计合并患病率。进行亚组分析和多变量meta回归以调查异质性的来源。
结果：与感染者（感染病例）密切接触（密切接触）的人中SFTSVRNA的合并患病率为5.59％（95％置信区间[CI]2.78-9.15％），在流行地区的健康个体中为0.05％（95％CI0.00-0.65％）。偶蹄动物(5.60%;95%CI2.95-8.96%)和食肉动物(6.34%;95%CI3.27-10.23%)的SFTSV感染率高于啮齿动物(0.45%;95%CI0.00-1.50%)。其他动物,比如兔子,刺猬和鸟类，在SFTSV传输中也发挥了重要作用。嗜血杆菌属是主要的传播媒介，与Ixodes的成员，Dermacentor,和弱虫也被确定为潜在的载体。在成年蜱中观察到最高的合并患病率（1.03%；95%CI0.35-1.96%），其次是若虫（0.66％；95％CI0.11-1.50％）和幼虫（0.01％；95％CI0.00-0.46％）。从流行地区收集的蜱的合并患病率（1.86％；95％CI0.86-3.14％）高于其他地区收集的蜱的合并患病率（0.41％；95％CI0.12-0.81％）。
结论：住在流行地区的健康个体中存在潜在的SFTSV感染，与SFTS病例密切接触者的感染风险明显更高。动物的类型与脊椎动物宿主的感染率有关，而蜱的感染率与发育阶段有关。需要进一步的研究来研究各种环境因素对脊椎动物宿主和蜱中SFTSV流行的影响。
方法：进行了系统综述和荟萃分析，以确定SFTSVRNA在人类中的患病率，脊椎动物寄主和寻找蜱。检索了九个电子数据库,寻找有关出版物,并提取SFTSVRNA流行数据。使用随机效应模型估计合并患病率。进行亚组分析和多变量meta回归以调查异质性的来源。
结果：与感染者（感染病例）密切接触（密切接触）的人中SFTSVRNA的合并患病率为5.59％（95％置信区间[CI]2.78-9.15％），在流行地区的健康个体中为0.05％（95％CI0.00-0.65％）。偶蹄动物(5.60%;95%CI2.95-8.96%)和食肉动物(6.34%;95%CI3.27-10.23%)的SFTSV感染率高于啮齿动物(0.45%;95%CI0.00-1.50%)。其他动物,比如兔子,刺猬和鸟类，在SFTSV传输中也发挥了重要作用。嗜血杆菌属是主要的传播媒介，与Ixodes的成员，Dermacentor,和弱虫也被确定为潜在的载体。在成年蜱中观察到最高的合并患病率（1.03%；95%CI0.35-1.96%），其次是若虫（0.66％；95％CI0.11-1.50％）和幼虫（0.01％；95％CI0.00-0.46％）。从流行地区收集的蜱的合并患病率（1.86％；95％CI0.86-3.14％）高于其他地区收集的蜱的合并患病率（0.41％；95％CI0.12-0.81％）。
结论：住在流行地区的健康个体中存在潜在的SFTSV感染，与SFTS病例密切接触者的感染风险明显更高。动物的类型与脊椎动物宿主的感染率有关，而蜱的感染率与发育阶段有关。需要进一步的研究来研究各种环境因素对脊椎动物宿主和蜱中SFTSV流行的影响。
