Abstract：
Cell-penetrating peptides (CPPs) are short (typically 5-30 amino acids), cationic, amphipathic, or hydrophobic peptides that facilitate the cellular uptake of diverse cargo molecules by eukaryotic cells via direct translocation or endocytosis across the plasma membrane. CPPs can deliver a variety of bioactive cargos, including proteins, peptides, nucleic acids, and small molecules into the cell. Once inside, the delivered cargo may function in the cytosol, nucleus, or other subcellular compartments. Numerous CPPs have been used for studies and drug delivery in mammalian systems. Although CPPs have many potential uses in plant research and agriculture, the application of CPPs in plants remains limited. Here we review the structures and mechanisms of CPPs and highlight their potential applications for sustainable agriculture.
摘要：
细胞穿透肽（CPPs）短（通常为5-30个氨基酸），阳离子,两亲性,或疏水性肽，其促进真核细胞通过跨质膜的直接易位或内吞作用对多种货物分子的细胞摄取。CPPs可以运送多种生物活性货物，包括蛋白质，肽，核酸,和小分子进入细胞。一旦进去，递送的货物可能在细胞质中起作用，核，或其他亚细胞区室。许多CPP已用于哺乳动物系统中的研究和药物递送。尽管CPPs在植物研究和农业中具有许多潜在用途，CPPs在植物中的应用仍然有限。在这里，我们回顾了CPP的结构和机制，并强调了它们在可持续农业中的潜在应用。
