基因间风险变异 rs56258221 通过 miR4464 - BACH2 相互作用在原发性硬化性胆管炎中扭曲了幼稚 CD4 + T 细胞的命运。
关键词: BACH2 CD4 T cells TH17 cells genetic polymorphism immune-mediated liver disease miR4464 naive T cells primary sclerosing cholangitis regulatory T cells
Mesh : Humans Cholangitis, Sclerosing / genetics pathology immunology MicroRNAs / genetics metabolism CD4-Positive T-Lymphocytes / immunology metabolism Basic-Leucine Zipper Transcription Factors / genetics metabolism Male Polymorphism, Single Nucleotide / genetics Female Genetic Predisposition to Disease Adult Middle Aged
来 源:
DOI:10.1016/j.xcrm.2024.101620
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