Abstract：
BACKGROUND: France has the sixth highest incidence of oropharyngeal cancer (OPC) in Europe, but the epidemiological impact of high-risk HPV (HR-HPV) remains poorly documented. The objective of our study was to assess the proportion of OPCs caused by HR-HPV in Paris, and its suburbs, over the four past decades. This area accounts for almost one-fifth of the total population of France.
METHODS: OPCs diagnosed in 1981, 1986, 1991, 1996, 2001, 2006, 2011, 2016 and 2020/2021 in two of the main referral cancer centers for HNCs in Paris and its suburbs were retrieved from the tumor biobanks. HPV status was determined by p16-staining and HPV-DNA detection. Samples were considered HPV-driven if both assays were positive. Results were compared to the French cancer registry data.
RESULTS: Samples from 697 OPC patients were assessed (including 82 % of all samples diagnosed in 2001, 2006, 2011, 2016, 2021). The proportion of HPV-driven cases rose from 2.7 % to 53 % between 1981 and 2021. HPV16 was the dominant genotype during the study period. Of patients with HPV-driven OPC, 81 % were male and 42 % were smokers versus 80 % and 92 % in their HPV-negative counterparts. The age of OPC patients increased significantly, during the study period, independent of their HPV status CONCLUSION: The proportion of HPV-driven OPCs has significantly increased in Paris and its suburbs, during the last four decades. OPCs has become the 2nd predominant type of head and neck cancer, in France. This may be linked to the rise in HPV-driven cases and the decrease of tobacco and alcohol consumption in men.
METHODS: OPCs diagnosed in 1981, 1986, 1991, 1996, 2001, 2006, 2011, 2016 and 2020/2021 in two of the main referral cancer centers for HNCs in Paris and its suburbs were retrieved from the tumor biobanks. HPV status was determined by p16-staining and HPV-DNA detection. Samples were considered HPV-driven if both assays were positive. Results were compared to the French cancer registry data.
RESULTS: Samples from 697 OPC patients were assessed (including 82 % of all samples diagnosed in 2001, 2006, 2011, 2016, 2021). The proportion of HPV-driven cases rose from 2.7 % to 53 % between 1981 and 2021. HPV16 was the dominant genotype during the study period. Of patients with HPV-driven OPC, 81 % were male and 42 % were smokers versus 80 % and 92 % in their HPV-negative counterparts. The age of OPC patients increased significantly, during the study period, independent of their HPV status CONCLUSION: The proportion of HPV-driven OPCs has significantly increased in Paris and its suburbs, during the last four decades. OPCs has become the 2nd predominant type of head and neck cancer, in France. This may be linked to the rise in HPV-driven cases and the decrease of tobacco and alcohol consumption in men.
摘要：
背景：法国在欧洲的口咽癌（OPC）发病率排名第六，但高危型HPV(HR-HPV)的流行病学影响仍未得到充分记录.我们研究的目的是评估巴黎HR-HPV引起的OPCs比例，和它的郊区，在过去的四十年里。该地区几乎占法国总人口的五分之一。
方法：在巴黎及其郊区的两个主要的HNC转诊癌症中心于1981年、1986年、1991年、1996年、2001年、2006年、2011年、2016年和2020年/2021年诊断的OPCs从肿瘤生物库中检索。通过p16染色和HPV-DNA检测确定HPV状态。如果两个测定都是阳性的,则认为样品是HPV驱动的。将结果与法国癌症登记数据进行比较。
结果：评估了697名OPC患者的样本（包括2001年，2006年，2011年，2016年，2021年诊断的所有样本的82％）。从1981年到2021年，HPV驱动的病例比例从2.7%上升到53%。HPV16是研究期间的优势基因型。HPV驱动的OPC患者，81%为男性，42%为吸烟者，而HPV阴性者为80%和92%。OPC患者的年龄显著增加，在学习期间，结论：巴黎及其郊区HPV驱动的OPCs比例显著增加，在过去的四十年里。OPCs已成为头颈癌的第二主要类型，在法国。这可能与HPV驱动病例的增加以及男性烟草和酒精消费的减少有关。
方法：在巴黎及其郊区的两个主要的HNC转诊癌症中心于1981年、1986年、1991年、1996年、2001年、2006年、2011年、2016年和2020年/2021年诊断的OPCs从肿瘤生物库中检索。通过p16染色和HPV-DNA检测确定HPV状态。如果两个测定都是阳性的,则认为样品是HPV驱动的。将结果与法国癌症登记数据进行比较。
结果：评估了697名OPC患者的样本（包括2001年，2006年，2011年，2016年，2021年诊断的所有样本的82％）。从1981年到2021年，HPV驱动的病例比例从2.7%上升到53%。HPV16是研究期间的优势基因型。HPV驱动的OPC患者，81%为男性，42%为吸烟者，而HPV阴性者为80%和92%。OPC患者的年龄显著增加，在学习期间，结论：巴黎及其郊区HPV驱动的OPCs比例显著增加，在过去的四十年里。OPCs已成为头颈癌的第二主要类型，在法国。这可能与HPV驱动病例的增加以及男性烟草和酒精消费的减少有关。
