PDF(Pubmed)
Abstract：
Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
摘要：
尽管在流行地区持续爆发黄热病病毒（YFV），关于其环境稳定性或有效灭活指南的数据有限。这里,我们评估了YFV17D疫苗株对乙醇灭活的敏感性，2-丙醛,世界卫生组织（WHO）-推荐的手擦配方I和II，以及表面消毒剂。此外,通过WHO推荐的手擦制剂I和II测试了两种致病菌株，以比较灭活动力学。此外，评估了疫苗株的环境稳定性。YFV17D颗粒在室温下显示约13天的感染性半衰期衰减曲线。尽管环境稳定，YFV被醇有效灭活，世卫组织推荐的手工配方，和五种经测试的表面消毒剂中的四种。这些结果可用于定义防止非媒介传播的YFV传播的消毒方案。
