Abstract：
Background: Third molar removal is the primary reason for inferior alveolar nerve (IAN) damage, with 2% causing persistent neurosensory deficits. This study aimed to investigate how delayed photobiomodulation therapy affects long-lasting neurosensory disturbances. Methods: This study was conducted on patients with neurosensory disturbances lasting longer than 6 months. Patients were randomly allocated to the study and control groups, with the study group receiving a low-power diode laser (continuous wavelength of 810 nm, power of 200 mW) on 16 points (30 sec at each) for 12 sessions (2 sessions/week), while the control group received a placebo treatment by switched-off laser probe. Visual analog scale (VAS; ranging from 1 to 5), static light touch, two-point discrimination, direction discrimination, pinprick, and thermal discrimination tests were performed on each visit up to 9 months post-therapy to evaluate the recovery status. Results: Each group comprised 18 participants. The mean time since injury was 8.26 ± 2.05 and 8.38 ± 1.98 months for the control and intervention groups, respectively (p = 0.81). There was a significant improvement in the intervention group on the static light touch (p = 0.041), two-point discrimination (p = 0.028), VAS (p = 0.031), and pinprick (p = 0.014) tests on the 11th session and subsequent visits and also on direction discrimination test on the 12th session (p = 0.044) and after that. There was no significant difference in the thermal discrimination tests between the two groups (p > 0.05). Conclusion: Photobiomodulation demonstrated potential benefits in resolving persistent neurosensory deficits of the IAN, with noticeable improvements typically observed after around 35 days of treatment initiation (10 sessions).
摘要：
背景:第三磨牙切除是下牙槽神经(IAN)损伤的主要原因,2%导致持续的神经感觉缺陷。这项研究旨在研究延迟光生物调节疗法如何影响持久的神经感觉障碍。方法：这项研究是对神经感觉障碍持续时间超过6个月的患者进行的。患者随机分为研究组和对照组,研究组接受低功率二极管激光器（连续波长为810nm，200mW的功率)在16个点(每个30秒)上进行12个疗程(2个疗程/周)，而对照组则通过关闭激光探针接受安慰剂治疗。视觉模拟量表（VAS；范围从1到5），静态轻触，两点歧视，方向歧视,针刺,在治疗后9个月内对每次访视进行热辨别测试,以评估恢复状态.结果：每组18名参与者。对照组和干预组的平均伤后时间分别为8.26±2.05和8.38±1.98个月,分别(p=0.81)。干预组在静光触感上有显著改善(p=0.041),两点判别(p=0.028)，VAS（p=0.031），在第11届会议和随后的访问中进行针刺（p=0.014）测试，在第12届会议（p=0.044）和之后进行方向判别测试。两组热辨别试验无显著差异(p>0.05)。结论：光生物调节在解决IAN的持续性神经感觉缺陷方面显示出潜在的益处，通常在开始治疗约35天后观察到显着的改善（10个疗程）。
