PDF(Pubmed)
Abstract：
Brain structural circuitry shapes a richly patterned functional synchronization, supporting for complex cognitive and behavioural abilities. However, how coupling of structural connectome (SC) and functional connectome (FC) develops and its relationships with cognitive functions and transcriptomic architecture remain unclear. We used multimodal magnetic resonance imaging data from 439 participants aged 5.7-21.9 years to predict functional connectivity by incorporating intracortical and extracortical structural connectivity, characterizing SC-FC coupling. Our findings revealed that SC-FC coupling was strongest in the visual and somatomotor networks, consistent with evolutionary expansion, myelin content, and functional principal gradient. As development progressed, SC-FC coupling exhibited heterogeneous alterations dominated by an increase in cortical regions, broadly distributed across the somatomotor, frontoparietal, dorsal attention, and default mode networks. Moreover, we discovered that SC-FC coupling significantly predicted individual variability in general intelligence, mainly influencing frontoparietal and default mode networks. Finally, our results demonstrated that the heterogeneous development of SC-FC coupling is positively associated with genes in oligodendrocyte-related pathways and negatively associated with astrocyte-related genes. This study offers insight into the maturational principles of SC-FC coupling in typical development.
摘要：
大脑结构电路形成了丰富模式的功能同步，支持复杂的认知和行为能力。然而,结构连接体(SC)和功能连接体(FC)的偶联如何发展及其与认知功能和转录组结构的关系仍不清楚.我们使用来自439名年龄在5.7-21.9岁的参与者的多模态磁共振成像数据，通过结合皮质内和皮质外结构连通性来预测功能连通性。表征SC-FC耦合。我们的发现表明，SC-FC耦合在视觉和躯体运动网络中最强，与进化扩张一致，髓鞘含量,和功能主梯度。随着发展的进步,SC-FC偶联表现出由皮质区域增加主导的异质性改变，广泛分布在整个躯体运动中，额顶叶,背侧注意力,和默认模式网络。此外，我们发现SC-FC耦合显着预测一般智力的个体变异性，主要影响额叶和默认模式网络。最后,我们的结果表明,SC-FC偶联的异质性发育与少突胶质细胞相关通路中的基因呈正相关,与星形胶质细胞相关基因呈负相关.这项研究提供了对典型发展中SC-FC耦合的成熟原理的见解。
