Abstract：
OBJECTIVE: Breast cancer-related arm lymphedema (BCRL) is a common chronic and debilitating condition that involves accumulation of lymphatic fluid in the arm or hand. Limited data are available on BCRL in African American women. Lack of physical activity (PA) and poor physical functioning (PF) are both associated with increased morbidity and mortality among breast cancer survivors. We examined the association of BCRL with PA and PF among African American breast cancer survivors.
METHODS: 323 African American women who previously participated in a case-only study in three states (TN, GA, SC) completed a survivorship-focused questionnaire (mean: 4.2 years post-diagnosis) in 2015-2016. Validated measures were used to determine BCRL, PF, and PA. Adjusted binary logistic regression models estimated ORs and 95% CIs for the association of BCRL and meeting PA guidelines (≥ 150 min/week), while multinomial logistic regression was used for PF and PA (minutes/week) categorized based on tertiles.
RESULTS: Approximately 32% reported BCRL since diagnosis; 25.4% reported BCRL in the last 12-months. About 26% and 50% reported that BCRL interfered with exercise and ability to do daily activities, respectively. The mean PF among those with BCRL was 51.0(SD:29.0) vs. 68.5(SD:30.1) among those without BCRL. BCRL was associated with lower PF (adjusted-OR for tertile 2: 2.12(95% CI:1.03-4.36) and adjusted-OR for tertile 1: 2.93(95% CI:1.44-5.96)).
CONCLUSIONS: BCRL was associated with lower PF among long-term African American breast cancer survivors. Continued monitoring by health care professionals and increased education and behavioral interventions to support PA and improved PF among survivors living with BCRL are warranted.
METHODS: 323 African American women who previously participated in a case-only study in three states (TN, GA, SC) completed a survivorship-focused questionnaire (mean: 4.2 years post-diagnosis) in 2015-2016. Validated measures were used to determine BCRL, PF, and PA. Adjusted binary logistic regression models estimated ORs and 95% CIs for the association of BCRL and meeting PA guidelines (≥ 150 min/week), while multinomial logistic regression was used for PF and PA (minutes/week) categorized based on tertiles.
RESULTS: Approximately 32% reported BCRL since diagnosis; 25.4% reported BCRL in the last 12-months. About 26% and 50% reported that BCRL interfered with exercise and ability to do daily activities, respectively. The mean PF among those with BCRL was 51.0(SD:29.0) vs. 68.5(SD:30.1) among those without BCRL. BCRL was associated with lower PF (adjusted-OR for tertile 2: 2.12(95% CI:1.03-4.36) and adjusted-OR for tertile 1: 2.93(95% CI:1.44-5.96)).
CONCLUSIONS: BCRL was associated with lower PF among long-term African American breast cancer survivors. Continued monitoring by health care professionals and increased education and behavioral interventions to support PA and improved PF among survivors living with BCRL are warranted.
摘要：
目的：乳腺癌相关的手臂淋巴水肿（BCRL）是一种常见的慢性和衰弱的疾病，涉及淋巴液在手臂或手部的积累。关于非洲裔美国妇女的BCRL数据有限。缺乏身体活动（PA）和不良的身体功能（PF）都与乳腺癌幸存者的发病率和死亡率增加有关。我们在非裔美国人乳腺癌幸存者中检查了BCRL与PA和PF的关联。
方法：323名以前参加过三个州的仅案例研究的非洲裔美国妇女（TN，GA,SC）在2015-2016年完成了以生存为重点的问卷（平均：诊断后4.2年）。使用验证的措施来确定BCRL，PF,和PA。调整后的二元逻辑回归模型估计了BCRL和符合PA指南(≥150分钟/周)的关联的OR和95%CI。而多项逻辑回归用于基于三元组分类的PF和PA(分钟/周)。
结果：大约32%报告了诊断后的BCRL；25.4%报告了最近12个月的BCRL。大约26％和50％的人报告说BCRL干扰了运动和进行日常活动的能力，分别。BCRL患者的平均PF为51.0（SD：29.0）。68.5（SD：30.1）在那些没有BCRL。BCRL与较低的PF（三元组2的校正OR：2.12（95％CI：1.03-4.36）和三元组1的校正OR：2.93（95％CI：1.44-5.96））相关。
结论：在长期非裔美国人乳腺癌幸存者中，BCRL与较低的PF相关。有必要由卫生保健专业人员继续监测，并增加教育和行为干预措施，以支持患有BCRL的幸存者中的PA和改善的PF。
方法：323名以前参加过三个州的仅案例研究的非洲裔美国妇女（TN，GA,SC）在2015-2016年完成了以生存为重点的问卷（平均：诊断后4.2年）。使用验证的措施来确定BCRL，PF,和PA。调整后的二元逻辑回归模型估计了BCRL和符合PA指南(≥150分钟/周)的关联的OR和95%CI。而多项逻辑回归用于基于三元组分类的PF和PA(分钟/周)。
结果：大约32%报告了诊断后的BCRL；25.4%报告了最近12个月的BCRL。大约26％和50％的人报告说BCRL干扰了运动和进行日常活动的能力，分别。BCRL患者的平均PF为51.0（SD：29.0）。68.5（SD：30.1）在那些没有BCRL。BCRL与较低的PF（三元组2的校正OR：2.12（95％CI：1.03-4.36）和三元组1的校正OR：2.93（95％CI：1.44-5.96））相关。
结论：在长期非裔美国人乳腺癌幸存者中，BCRL与较低的PF相关。有必要由卫生保健专业人员继续监测，并增加教育和行为干预措施，以支持患有BCRL的幸存者中的PA和改善的PF。
