PDF(Pubmed)
Abstract：
UNASSIGNED: Common postoperative complications following surgery, particularly acute appendicitis surgery, include postoperative pain and vomiting, which can cause discomfort and delay recovery time.
UNASSIGNED: A randomized double-blinded placebo-controlled clinical trial was conducted with 80 cases of acute appendicitis of American Society of Anesthesiologists (ASA) physical status I or II and aged 18-60 y/o scheduled for appendectomy under general anesthesia. Patients were randomly divided into two equal groups: group A received 4 mg of ondansetron IV (2 ml) and group B received 2 ml of normal slain IV (placebo). Pain according to VAS, nausea and vomiting according to clinical symptoms, shivering and sedation according to the Bedside Shivering Assessment Scale (BSAS), and the Ramsay Sedation Scale (RSS) at 2, 6, 12, and 24 hours after surgery were evaluated and compared between the groups.
UNASSIGNED: There was a significant decline in the severity of pain only at 2 hours after surgery between the ondansetron and control groups (5.3 ± 1.0 vs. 6.0 ± 1.0; p=0.01), not showing a difference between the groups at 6, 12, and 24 hours after appendectomy. Postoperative nausea and vomiting at 2 (5% vs. 25%; p=0.03) and 6 (7.5% vs. 27.5%; p=0.04) hours after appendectomy in the ondansetron group. At different times, the ondansetron and control groups did not differ in terms of pethidine consumption or sedation.
UNASSIGNED: In conclusion, our study found that ondansetron was effective in reducing postoperative vomiting after acute appendicitis surgery. However, it did not show a clinically significant effect on postoperative pain. This trial is registered with IRCT20230722058883N1.
UNASSIGNED: A randomized double-blinded placebo-controlled clinical trial was conducted with 80 cases of acute appendicitis of American Society of Anesthesiologists (ASA) physical status I or II and aged 18-60 y/o scheduled for appendectomy under general anesthesia. Patients were randomly divided into two equal groups: group A received 4 mg of ondansetron IV (2 ml) and group B received 2 ml of normal slain IV (placebo). Pain according to VAS, nausea and vomiting according to clinical symptoms, shivering and sedation according to the Bedside Shivering Assessment Scale (BSAS), and the Ramsay Sedation Scale (RSS) at 2, 6, 12, and 24 hours after surgery were evaluated and compared between the groups.
UNASSIGNED: There was a significant decline in the severity of pain only at 2 hours after surgery between the ondansetron and control groups (5.3 ± 1.0 vs. 6.0 ± 1.0; p=0.01), not showing a difference between the groups at 6, 12, and 24 hours after appendectomy. Postoperative nausea and vomiting at 2 (5% vs. 25%; p=0.03) and 6 (7.5% vs. 27.5%; p=0.04) hours after appendectomy in the ondansetron group. At different times, the ondansetron and control groups did not differ in terms of pethidine consumption or sedation.
UNASSIGNED: In conclusion, our study found that ondansetron was effective in reducing postoperative vomiting after acute appendicitis surgery. However, it did not show a clinically significant effect on postoperative pain. This trial is registered with IRCT20230722058883N1.
摘要：
■手术后常见的术后并发症，特别是急性阑尾炎手术，包括术后疼痛和呕吐，这可能会导致不适和延迟恢复时间。
■对80例急性阑尾炎患者进行了一项随机双盲安慰剂对照临床试验，这些患者是美国麻醉医师协会（ASA）的体格状态I或II，年龄18-60岁，计划在全身麻醉下进行阑尾切除术。将患者随机分为两个相等的组：A组接受4mg的昂丹司琼IV（2ml），B组接受2ml的正常致死IV（安慰剂）。根据VAS疼痛，根据临床症状，恶心和呕吐，根据床边颤抖评估量表（BSAS），颤抖和镇静术后2、6、12、24h分别采用Ramsay镇静量表(RSS)进行评价和组间比较。
■昂丹司琼和对照组仅在手术后2小时疼痛的严重程度显着下降（5.3±1.0vs.6.0±1.0；p=0.01），在阑尾切除术后6,12和24小时，两组之间没有差异。术后2时恶心和呕吐(5%vs.25%；p=0.03）和6（7.5%与昂丹司琼组阑尾切除术后27.5％；p=0.04）小时。在不同的时间,昂丹司琼和对照组在哌替啶消耗或镇静方面没有差异.
■总而言之，我们的研究发现，昂丹司琼可有效减少急性阑尾炎手术后的呕吐。然而,它对术后疼痛没有临床显著影响.该试验已在IRCT20230722058883N1注册。
■对80例急性阑尾炎患者进行了一项随机双盲安慰剂对照临床试验，这些患者是美国麻醉医师协会（ASA）的体格状态I或II，年龄18-60岁，计划在全身麻醉下进行阑尾切除术。将患者随机分为两个相等的组：A组接受4mg的昂丹司琼IV（2ml），B组接受2ml的正常致死IV（安慰剂）。根据VAS疼痛，根据临床症状，恶心和呕吐，根据床边颤抖评估量表（BSAS），颤抖和镇静术后2、6、12、24h分别采用Ramsay镇静量表(RSS)进行评价和组间比较。
■昂丹司琼和对照组仅在手术后2小时疼痛的严重程度显着下降（5.3±1.0vs.6.0±1.0；p=0.01），在阑尾切除术后6,12和24小时，两组之间没有差异。术后2时恶心和呕吐(5%vs.25%；p=0.03）和6（7.5%与昂丹司琼组阑尾切除术后27.5％；p=0.04）小时。在不同的时间,昂丹司琼和对照组在哌替啶消耗或镇静方面没有差异.
■总而言之，我们的研究发现，昂丹司琼可有效减少急性阑尾炎手术后的呕吐。然而,它对术后疼痛没有临床显著影响.该试验已在IRCT20230722058883N1注册。
