PDF(Pubmed)
Abstract：
BACKGROUND: Influenza is a main cause of illnesses during seasonal outbreaks. Identifying children with influenza who may need hospitalization may lead to better influenza outcomes.
OBJECTIVE: To identify factors associated with the severity of influenza infection, specifically among children who were admitted to the hospital after being diagnosed with influenza at the emergency department.
METHODS: A retrospective cohort study was conducted among pediatric patients (age < 18 years) with a positive influenza rapid test who visited the emergency department at Srinagarind hospital between January2015-December2019. The dependent variable was hospital admission, while the independent variables included clinical parameters, laboratory results, and emergency severity index(ESI). The association between these variables and hospital admission was analyzed.
RESULTS: There were 542 cases of influenza included in the study. The mean age was 7.50 ± 4.52 years. Males accounted for 52.4% of the cases. A total of 190(35.05%) patients, needed hospitalization. Patients with pneumonia, those who required hospitalization or were admitted to the critical care unit, consistently exhibited an elevated absolute monocyte count and a reduced lymphocyte-to-monocyte ratio (LMR). Various factors contribute to an increased risk for hospitalization, including ESI level 1-2, co-morbidity in patients, age < 1 year old, and an LMR below 2.
CONCLUSIONS: ESI level 1-2 and co-morbidity in patients represent significant risk factors that contribute to higher hospitalization admissions. A LMR below 2 can be used as a prognostic marker for hospitalization in children with influenza infection.
OBJECTIVE: To identify factors associated with the severity of influenza infection, specifically among children who were admitted to the hospital after being diagnosed with influenza at the emergency department.
METHODS: A retrospective cohort study was conducted among pediatric patients (age < 18 years) with a positive influenza rapid test who visited the emergency department at Srinagarind hospital between January2015-December2019. The dependent variable was hospital admission, while the independent variables included clinical parameters, laboratory results, and emergency severity index(ESI). The association between these variables and hospital admission was analyzed.
RESULTS: There were 542 cases of influenza included in the study. The mean age was 7.50 ± 4.52 years. Males accounted for 52.4% of the cases. A total of 190(35.05%) patients, needed hospitalization. Patients with pneumonia, those who required hospitalization or were admitted to the critical care unit, consistently exhibited an elevated absolute monocyte count and a reduced lymphocyte-to-monocyte ratio (LMR). Various factors contribute to an increased risk for hospitalization, including ESI level 1-2, co-morbidity in patients, age < 1 year old, and an LMR below 2.
CONCLUSIONS: ESI level 1-2 and co-morbidity in patients represent significant risk factors that contribute to higher hospitalization admissions. A LMR below 2 can be used as a prognostic marker for hospitalization in children with influenza infection.
摘要：
背景：流感是季节性爆发期间疾病的主要原因。确定可能需要住院治疗的流感儿童可能会导致更好的流感结局。
目的：确定与流感感染严重程度相关的因素，特别是在急诊室被诊断为流感后入院的儿童中。
方法：在2015年1月至2019年12月期间就诊于斯利那加林德医院急诊科的流感快速检测阳性的儿科患者（年龄<18岁）中进行了一项回顾性队列研究。因变量是入院，而自变量包括临床参数，实验室结果,和紧急严重性指数（ESI）。分析了这些变量与入院之间的关联。
结果：研究中纳入了542例流感病例。平均年龄为7.50±4.52岁。男性占52.4%。共190例(35.05%)患者,需要住院治疗。肺炎患者,那些需要住院治疗或被送进重症监护病房的人，始终显示单核细胞绝对计数升高和淋巴细胞与单核细胞比率（LMR）降低。各种因素导致住院风险增加，包括ESI1-2级，患者合并症，年龄<1岁，LMR低于2。
结论：患者的ESI1-2级和合并症是导致住院人数增加的重要危险因素。低于2的LMR可用作流感感染儿童住院的预后标志物。
目的：确定与流感感染严重程度相关的因素，特别是在急诊室被诊断为流感后入院的儿童中。
方法：在2015年1月至2019年12月期间就诊于斯利那加林德医院急诊科的流感快速检测阳性的儿科患者（年龄<18岁）中进行了一项回顾性队列研究。因变量是入院，而自变量包括临床参数，实验室结果,和紧急严重性指数（ESI）。分析了这些变量与入院之间的关联。
结果：研究中纳入了542例流感病例。平均年龄为7.50±4.52岁。男性占52.4%。共190例(35.05%)患者,需要住院治疗。肺炎患者,那些需要住院治疗或被送进重症监护病房的人，始终显示单核细胞绝对计数升高和淋巴细胞与单核细胞比率（LMR）降低。各种因素导致住院风险增加，包括ESI1-2级，患者合并症，年龄<1岁，LMR低于2。
结论：患者的ESI1-2级和合并症是导致住院人数增加的重要危险因素。低于2的LMR可用作流感感染儿童住院的预后标志物。
