Abstract：
Dementia treatment has become a global research priority, driven by the increase in the aging population. Punicalagin, the primary polyphenol found in pomegranate fruit, exhibits a variety of benefits. Today, a growing body of research is showing that punicalagin is a nutraceutical for the prevention of mild cognitive impairment (MCI). However, a comprehensive review is still lacking. The aim of this paper is to provide a comprehensive review of the physicochemical properties, origin and pharmacokinetics of punicalagin, while emphasizing the significance and mechanisms of its potential role in the prevention and treatment of MCI. Preclinical and clinical studies have demonstrated that Punicalagin possesses the potential to effectively target and enhance the treatment of MCI. Potential mechanisms by which punicalagin alleviates MCI include antioxidative damage, anti-neuroinflammation, promotion of neurogenesis, and modulation of neurotransmitter interactions. Overall, punicalagin is safer and shows potential as a therapeutic compound for the prevention and treatment of MCI, although more rigorous randomized controlled trials involving large populations are required.
摘要：
痴呆症治疗已成为全球研究重点，在人口老龄化的推动下。Punicalagin,石榴果实中的主要多酚，展示了各种好处。今天,越来越多的研究表明，punicalagin是预防轻度认知障碍（MCI）的营养药物。然而,仍然缺乏全面的审查。本文的目的是提供对物理化学性质的全面回顾，punicalagin的来源和药代动力学，同时强调其在MCI预防和治疗中的潜在作用的重要性和机制。临床前和临床研究表明，Punicalagin具有有效靶向和增强MCI治疗的潜力。punicalagin缓解MCI的潜在机制包括抗氧化损伤，抗神经炎症，促进神经发生，和调节神经递质的相互作用。总的来说,punicalagin更安全,并且显示出作为MCI预防和治疗的治疗化合物的潜力,尽管需要更严格的涉及大量人群的随机对照试验.
