PDF(Pubmed)
Abstract：
BACKGROUND: Dengue is a disease that accounts for a major morbidity and mortality in Honduras.
METHODS: This descriptive study used an analytical component based on the data from the National Virology Laboratory between 2016-2022. Ordinal logistic regression was used to identify the factors associated with the classification of dengue without warning signs (DWOS), dengue with warning signs (DWS), and severe dengue (SD).
RESULTS: Overall, 14,687 dengue cases were included; 50.1% had DWOS, 36.5% had DWS, and 13.4% had SD. Patients that were more associated with a higher probability of DWS and SD were patients in the age groups 1-4 years (DWS OR 1.61; 95%CI:1.33-1.94), (SD OR 1.52; 95% CI:1.26-1.84), 5-9 years (DWS OR 2.01; 95% CI:1.68-2.40), (SD OR 2.00; 95% CI:1.67-2.40), and 10-19 years (DWS OR 1.55; 95% CI:1.30-1.85) (SD OR 1.57; 95% CI:1.31-1.88). The departments that were associated with a higher probability of DWS and SD were La Paz (OR 6.35; 95% CI:3.53-11.42), (OR 10.94; 95% CI:5.96-20.08), Copán (OR 6.94; 95% CI:5.05-9.53) (OR 7.33; 95% CI: 5.35-10.03), Valle (OR 5.22; 95% CI:1.25-21.82) (OR 10.71; 95% CI:2.21-51.88).
CONCLUSIONS: During the study period, dengue presented endemic behavior, with peaks consistent with the last two epidemics in Honduras in 2015 and 2019. The main factors associated with dengue severity were age< 19 years, male sex, and being from La Paz, Copán, or Valle.
METHODS: This descriptive study used an analytical component based on the data from the National Virology Laboratory between 2016-2022. Ordinal logistic regression was used to identify the factors associated with the classification of dengue without warning signs (DWOS), dengue with warning signs (DWS), and severe dengue (SD).
RESULTS: Overall, 14,687 dengue cases were included; 50.1% had DWOS, 36.5% had DWS, and 13.4% had SD. Patients that were more associated with a higher probability of DWS and SD were patients in the age groups 1-4 years (DWS OR 1.61; 95%CI:1.33-1.94), (SD OR 1.52; 95% CI:1.26-1.84), 5-9 years (DWS OR 2.01; 95% CI:1.68-2.40), (SD OR 2.00; 95% CI:1.67-2.40), and 10-19 years (DWS OR 1.55; 95% CI:1.30-1.85) (SD OR 1.57; 95% CI:1.31-1.88). The departments that were associated with a higher probability of DWS and SD were La Paz (OR 6.35; 95% CI:3.53-11.42), (OR 10.94; 95% CI:5.96-20.08), Copán (OR 6.94; 95% CI:5.05-9.53) (OR 7.33; 95% CI: 5.35-10.03), Valle (OR 5.22; 95% CI:1.25-21.82) (OR 10.71; 95% CI:2.21-51.88).
CONCLUSIONS: During the study period, dengue presented endemic behavior, with peaks consistent with the last two epidemics in Honduras in 2015 and 2019. The main factors associated with dengue severity were age< 19 years, male sex, and being from La Paz, Copán, or Valle.
摘要：
背景：登革热是洪都拉斯主要发病率和死亡率的一种疾病。
方法：这项描述性研究使用了基于2016-2022年国家病毒学实验室数据的分析成分。序数logistic回归用于确定与没有警告标志（DWOS）的登革热分类相关的因素，带有警告标志的登革热（DWS），和严重登革热（SD）。
结果：总体而言，纳入14,687例登革热病例；50.1%患有DWOS，36.5%有DWS，13.4%有SD。与DWS和SD的较高概率相关的患者是1-4岁年龄组的患者（DWSOR1.61;95CI：1.33-1.94），（SDOR1.52；95%CI：1.26-1.84），5-9年（DWSOR2.01；95%CI：1.68-2.40），（SDOR2.00；95%CI：1.67-2.40），和10-19年（DWSOR1.55；95%CI：1.30-1.85）（SDOR1.57；95%CI：1.31-1.88）。与DWS和SD的较高概率相关的部门是拉巴斯（OR6.35;95％CI：3.53-11.42），（OR10.94；95%CI：5.96-20.08），科潘（OR6.94；95%CI：5.05-9.53）（OR7.33；95%CI：5.35-10.03），Valle（OR5.22；95%CI：1.25-21.82）（OR10.71；95%CI：2.21-51.88）。
结论：在研究期间，登革热表现出特有的行为，峰值与2015年和2019年洪都拉斯最近两次疫情一致。与登革热严重程度相关的主要因素是年龄<19岁，男性,来自拉巴斯，科潘,或者Valle.
方法：这项描述性研究使用了基于2016-2022年国家病毒学实验室数据的分析成分。序数logistic回归用于确定与没有警告标志（DWOS）的登革热分类相关的因素，带有警告标志的登革热（DWS），和严重登革热（SD）。
结果：总体而言，纳入14,687例登革热病例；50.1%患有DWOS，36.5%有DWS，13.4%有SD。与DWS和SD的较高概率相关的患者是1-4岁年龄组的患者（DWSOR1.61;95CI：1.33-1.94），（SDOR1.52；95%CI：1.26-1.84），5-9年（DWSOR2.01；95%CI：1.68-2.40），（SDOR2.00；95%CI：1.67-2.40），和10-19年（DWSOR1.55；95%CI：1.30-1.85）（SDOR1.57；95%CI：1.31-1.88）。与DWS和SD的较高概率相关的部门是拉巴斯（OR6.35;95％CI：3.53-11.42），（OR10.94；95%CI：5.96-20.08），科潘（OR6.94；95%CI：5.05-9.53）（OR7.33；95%CI：5.35-10.03），Valle（OR5.22；95%CI：1.25-21.82）（OR10.71；95%CI：2.21-51.88）。
结论：在研究期间，登革热表现出特有的行为，峰值与2015年和2019年洪都拉斯最近两次疫情一致。与登革热严重程度相关的主要因素是年龄<19岁，男性,来自拉巴斯，科潘,或者Valle.
