METHODS: Twenty MRIs performed in children (< 18 years) were processed independently by two observers using a manual technique and using PFTquant. Interrater agreement in measured secreted fluid volume was compared using intraclass correlation coefficients, Bland-Altman difference analysis, and Dice similarity coefficients.
RESULTS: Interrater reliability of measured bowel fluid secretion using PFTquant was 0.90 (0.76-0.96 95% C.I.) with - 4.5 mL mean difference (-39.4-30.4 mL 95% limits of agreement) compared to 0.69 (0.36-0.86 95% C.I.) with - 0.9 mL mean difference (-77.3-75.5 mL 95% limits of agreement) for manual processing. Dice similarity coefficients were better using PFTquant (0.88 +/- 0.06) compared to manual processing (0.85 +/- 0.10) but not significantly (p = 0.11). Time to process was significantly (p < 0.001) faster using PFTquant (412 +/- 177 s) compared to manual processing (645 +/- 305 s).
CONCLUSIONS: Novel software provides fast, reliable quantification of secreted fluid volume in children undergoing MR-PFTs. Use of the novel software could facilitate wider adoption of quantitative MR-PFTs in clinical care and research.
方法:20例儿童(<18岁)的MRI由两名观察者使用手动技术和PFTquant独立处理。使用组内相关系数比较了测得的分泌液体体积的评分者之间的一致性,Bland-Altman差异分析,和骰子相似系数。
结果:使用PFTquant测量的肠液分泌的评估者间可靠性为0.90(0.76-0.9695%C.I.),平均差异为-4.5mL(-39.4-30.4mL95%一致界限),而手动处理为0.69(0.36-0.8695%C.I.),平均差异为-0.9mL(-77.3-75.5mL95%与手动处理(0.85+/-0.10)相比,使用PFTquant(0.88+/-0.06)的骰子相似性系数更好,但不显著(p=0.11)。与手动处理(645+/-305s)相比,使用PFTquant(412+/-177s)处理时间显著(p<0.001)更快。
结论:新颖的软件提供了快速,对接受MR-PFTs的儿童分泌的液体量进行可靠的定量。新软件的使用可以促进定量MR-PFTs在临床护理和研究中的更广泛采用。