PDF(Pubmed)
Abstract：
Breast and ovarian cancers, despite having chemotherapy and surgical treatment, still have the lowest survival rate. Experimental stages using nanoenzymes/nanozymes for ovarian cancer diagnosis and treatment are being carried out, and correspondingly the current treatment approaches to treat breast cancer have a lot of adverse side effects, which is the reason why researchers and scientists are looking for new strategies with less side effects. Nanoenzymes have intrinsic enzyme-like activities and can reduce the shortcomings of naturally occurring enzymes due to the ease of storage, high stability, less expensive, and enhanced efficiency. In this review, we have discussed various ways in which nanoenzymes are being used to diagnose and treat breast and ovarian cancer. For breast cancer, nanoenzymes and their multi-enzymatic properties can control the level of reactive oxygen species (ROS) in cells or tissues, for example, oxidase (OXD) and peroxidase (POD) activity can be used to generate ROS, while catalase (CAT) or superoxide dismutase (SOD) activity can scavenge ROS. In the case of ovarian cancer, most commonly nanoceria is being investigated, and also when folic acid is combined with nanoceria there are additional advantages like inhibition of beta galactosidase. Nanocarriers are also used to deliver small interfering RNA that are effective in cancer treatment. Studies have shown that iron oxide nanoparticles are actively being used for drug delivery, similarly ferritin carriers are used for the delivery of nanozymes. Hypoxia is a major factor in ovarian cancer, therefore MnO2-based nanozymes are being used as a therapy. For cancer diagnosis and screening, nanozymes are being used in sonodynamic cancer therapy for cancer diagnosis and screening, whereas biomedical imaging and folic acid gold particles are also being used for image guided treatments. Nanozyme biosensors have been developed to detect ovarian cancer. This review article summarizes a detailed insight into breast and ovarian cancers in light of nanozymes-based diagnostic and therapeutic approaches.
摘要：
乳腺癌和卵巢癌，尽管接受了化疗和手术治疗，存活率最低。正在进行使用纳米酶/纳米酶进行卵巢癌诊断和治疗的实验阶段，相应地，目前治疗乳腺癌的治疗方法有很多不良副作用，这就是为什么研究人员和科学家正在寻找副作用较小的新策略的原因。纳米酶具有内在的类酶活性，并且由于易于储存而可以减少天然存在的酶的缺点，高稳定性,更便宜，和提高效率。在这次审查中,我们已经讨论了纳米酶用于诊断和治疗乳腺癌和卵巢癌的各种方法。对于乳腺癌，纳米酶及其多酶特性可以控制细胞或组织中活性氧（ROS）的水平，例如,氧化酶(OXD)和过氧化物酶(POD)活性可用于产生ROS,过氧化氢酶（CAT）或超氧化物歧化酶（SOD）活性可以清除ROS。在卵巢癌的情况下，最常见的是研究纳米二氧化硅，并且当叶酸与纳米氧化铈结合时，还有其他优点，例如抑制β-半乳糖苷酶。纳米载体还用于递送在癌症治疗中有效的小干扰RNA。研究表明，氧化铁纳米颗粒正积极用于药物输送，类似地,铁蛋白载体用于递送纳米酶。缺氧是导致卵巢癌的主要因素,因此，基于MnO2的纳米酶被用作治疗。对于癌症诊断和筛查，纳米酶被用于癌症诊断和筛查的声动力学癌症治疗，而生物医学成像和叶酸金颗粒也被用于图像引导治疗。已经开发了纳米酶生物传感器来检测卵巢癌。这篇综述文章总结了基于纳米酶的诊断和治疗方法对乳腺癌和卵巢癌的详细见解。
