PDF(Pubmed)
Abstract：
UNASSIGNED: Alterations in body weight and composition are common in patients with chronic obstructive pulmonary disease (COPD) and are independent predictors for morbidity and mortality. Low vitamin D status is also more prevalent in patients with COPD compared to controls and has been related to lower lung function, muscle atrophy and impaired musculoskeletal function. This study aimed to evaluate the association between vitamin D levels and status with body composition (BC), as well as with its changes over time.
UNASSIGNED: Patients with COPD and controls without COPD, participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a prospective observational study, were included. Plasma 25-hydroxyvitamin D (25(OH)D) was measured at baseline and BC was measured by dual-energy X-ray absorptiometry scan, at baseline and after two years of follow-up. Multiple linear regression analyses were performed to assess the relationships between 25(OH)D (nmol/l) and longitudinal changes in BMI, fat-free mass index (FFMI), fat mas index (FMI) and bone mineral density (BMD).
UNASSIGNED: A total of 192 patients with COPD (57% males, mean ± SD age, 62 ± 7, FEV1, 49 ± 16% predicted) and 199 controls (45% males, mean ± SD age 61 ± 7) were included in this study. Vitamin D levels were significantly lower in patients with COPD (64 ± 26 nmol/L, 95% CI 60-68 nmol/L versus 75 ± 25 nmol/L, 95% CI 72-79 nmol/L) compared to controls. Both patients and controls presented a significant decline in FFMI and T-score hip, but vitamin D level or status did not determine differences in BC or changes in BC over time in either COPD or controls.
UNASSIGNED: Vitamin D status was not associated with BC or longitudinal changes in BC. However, vitamin D insufficiency and low BMD were more prevalent in patients with COPD compared to controls.
UNASSIGNED: Patients with COPD and controls without COPD, participating in the Individualized COPD Evaluation in relation to Ageing (ICE-Age) study, a prospective observational study, were included. Plasma 25-hydroxyvitamin D (25(OH)D) was measured at baseline and BC was measured by dual-energy X-ray absorptiometry scan, at baseline and after two years of follow-up. Multiple linear regression analyses were performed to assess the relationships between 25(OH)D (nmol/l) and longitudinal changes in BMI, fat-free mass index (FFMI), fat mas index (FMI) and bone mineral density (BMD).
UNASSIGNED: A total of 192 patients with COPD (57% males, mean ± SD age, 62 ± 7, FEV1, 49 ± 16% predicted) and 199 controls (45% males, mean ± SD age 61 ± 7) were included in this study. Vitamin D levels were significantly lower in patients with COPD (64 ± 26 nmol/L, 95% CI 60-68 nmol/L versus 75 ± 25 nmol/L, 95% CI 72-79 nmol/L) compared to controls. Both patients and controls presented a significant decline in FFMI and T-score hip, but vitamin D level or status did not determine differences in BC or changes in BC over time in either COPD or controls.
UNASSIGNED: Vitamin D status was not associated with BC or longitudinal changes in BC. However, vitamin D insufficiency and low BMD were more prevalent in patients with COPD compared to controls.
摘要：
体重和组成的改变在慢性阻塞性肺疾病（COPD）患者中很常见，并且是发病率和死亡率的独立预测因子。与对照组相比，低维生素D状态在COPD患者中也更普遍，并且与低肺功能有关。肌肉萎缩和肌肉骨骼功能受损。这项研究旨在评估维生素D水平和状态与身体成分（BC）之间的关系，以及它随时间的变化。
■COPD患者和无COPD的对照组，参与与老龄化相关的个体化COPD评估(ICE-Age)研究，一项前瞻性观察性研究，包括在内。在基线测量血浆25-羟基维生素D（25（OH）D），并通过双能X射线吸收法扫描测量BC，在基线和随访两年后。进行多元线性回归分析以评估25（OH）D（nmol/l）与BMI纵向变化之间的关系。无脂质量指数（FFMI），脂肪质量指数（FMI）和骨密度（BMD）。
■共有192名COPD患者（57%为男性，平均±SD年龄，62±7，FEV1，49±16%预测)和199个对照(45%男性，本研究包括平均±SD年龄61±7）。COPD患者的维生素D水平明显降低（64±26nmol/L，95%CI60-68nmol/L与75±25nmol/L，与对照组相比，95%CI72-79nmol/L)。患者和对照组均表现为FFMI和T评分髋部显著下降，但在COPD或对照组中,维生素D水平或状态不能确定BC的差异或BC随时间的变化.
■维生素D状态与BC或BC的纵向变化无关。然而,与对照组相比,COPD患者中维生素D不足和低BMD更为普遍.
■COPD患者和无COPD的对照组，参与与老龄化相关的个体化COPD评估(ICE-Age)研究，一项前瞻性观察性研究，包括在内。在基线测量血浆25-羟基维生素D（25（OH）D），并通过双能X射线吸收法扫描测量BC，在基线和随访两年后。进行多元线性回归分析以评估25（OH）D（nmol/l）与BMI纵向变化之间的关系。无脂质量指数（FFMI），脂肪质量指数（FMI）和骨密度（BMD）。
■共有192名COPD患者（57%为男性，平均±SD年龄，62±7，FEV1，49±16%预测)和199个对照(45%男性，本研究包括平均±SD年龄61±7）。COPD患者的维生素D水平明显降低（64±26nmol/L，95%CI60-68nmol/L与75±25nmol/L，与对照组相比，95%CI72-79nmol/L)。患者和对照组均表现为FFMI和T评分髋部显著下降，但在COPD或对照组中,维生素D水平或状态不能确定BC的差异或BC随时间的变化.
■维生素D状态与BC或BC的纵向变化无关。然而,与对照组相比,COPD患者中维生素D不足和低BMD更为普遍.
