PDF(Pubmed)
Abstract：
Cerebrospinal fluid (CSF) is a body fluid that can be used for the diagnosis of various diseases. However, CSF collection requires an invasive and painful procedure called a lumbar puncture (LP). This procedure is applied to any patient with a known risk of central nervous system (CNS) damage or neurodegenerative disease, regardless of their age range. Hence, this can be a very painful procedure, especially in infants and elderly patients. On the other hand, the detection of disease biomarkers in CSF makes diagnoses as accurate as possible. This review aims to explore novel electrochemical biosensing platforms that have impacted biomedical science. Biosensors have emerged as techniques to accelerate the detection of known biomarkers in body fluids such as CSF. Biosensors can be designed and modified in various ways and shapes according to their ultimate applications to detect and quantify biomarkers of interest. This process can also significantly influence the detection and diagnosis of CSF. Hence, it is important to understand the role of this technology in the rapidly progressing field of biomedical science.
摘要：
脑脊液（CSF）是一种可用于诊断各种疾病的体液。然而,CSF收集需要称为腰椎穿刺（LP）的侵入性和痛苦的程序。此程序适用于任何已知有中枢神经系统（CNS）损伤或神经退行性疾病风险的患者，不管他们的年龄范围。因此，这可能是一个非常痛苦的过程，尤其是婴儿和老年患者。另一方面,CSF中疾病生物标志物的检测使诊断尽可能准确.这篇综述旨在探索影响生物医学科学的新型电化学生物传感平台。生物传感器已经成为加速检测体液如CSF中已知生物标志物的技术。生物传感器可以根据其最终应用以各种方式和形状进行设计和修改,以检测和量化感兴趣的生物标志物。该过程还可以显著影响CSF的检测和诊断。因此，重要的是要了解这项技术在生物医学科学迅速发展的领域中的作用。
