PDF(Pubmed)
Abstract：
Epstein-Barr virus (EBV), Kaposi sarcoma human virus (KSHV), human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), human T-lymphotropic virus-1 (HTLV-1), and Merkel cell polyomavirus (MCPyV) are the seven human oncoviruses reported so far. While traditionally viewed as a benign virus causing mild symptoms in healthy individuals, human cytomegalovirus (HCMV) has been recently implicated in the pathogenesis of various cancers, spanning a wide range of tissue types and malignancies. This perspective article defines the biological criteria that characterize the oncogenic role of HCMV and based on new findings underlines a critical role for HCMV in cellular transformation and modeling the tumor microenvironment as already reported for the other human oncoviruses.
摘要：
EB病毒(EBV)卡波西肉瘤人类病毒（KSHV），人乳头瘤病毒（HPV），乙型肝炎和丙型肝炎病毒（HBV，HCV),人类嗜T淋巴细胞病毒-1（HTLV-1），默克尔细胞多瘤病毒（MCPyV）是迄今为止报道的七种人类肿瘤病毒。虽然传统上被认为是一种良性病毒，会在健康个体中引起轻微症状，人巨细胞病毒（HCMV）最近与各种癌症的发病机制有关，跨越广泛的组织类型和恶性肿瘤。这篇前瞻性文章定义了表征HCMV致癌作用的生物学标准，并基于新发现强调了HCMV在细胞转化和肿瘤微环境建模中的关键作用，正如已经报道的其他人类致癌病毒一样。
