{Reference Type}: Journal Article
{Title}: Cellular Transformation by Human Cytomegalovirus.
{Author}: Herbein G;
{Journal}: Cancers (Basel)
{Volume}: 16
{Issue}: 11
{Year}: 2024 May 22
{Factor}: 6.575
{DOI}: 10.3390/cancers16111970
{Abstract}: Epstein-Barr virus (EBV), Kaposi sarcoma human virus (KSHV), human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), human T-lymphotropic virus-1 (HTLV-1), and Merkel cell polyomavirus (MCPyV) are the seven human oncoviruses reported so far. While traditionally viewed as a benign virus causing mild symptoms in healthy individuals, human cytomegalovirus (HCMV) has been recently implicated in the pathogenesis of various cancers, spanning a wide range of tissue types and malignancies. This perspective article defines the biological criteria that characterize the oncogenic role of HCMV and based on new findings underlines a critical role for HCMV in cellular transformation and modeling the tumor microenvironment as already reported for the other human oncoviruses.