PDF(Pubmed)
Abstract：
The current state of the literature lacks a clear characterization of gastrointestinal (GI) symptoms, gut microbiota composition, and general physical and mental wellbeing in well-trained athletes. Therefore, this study aimed to characterize differences in self-reported symptoms, gut microbiota composition, and wellbeing (i.e., sleep quality, mood, and physical (PHQ) and mental wellbeing) between athletes with and without GI symptoms. In addition, we assessed the potential impact of a 3-week multi-ingredient fermented whey supplement in the GI complaints group, without a control group, on the gut microbiota and self-reported GI symptoms and wellbeing. A total of 50 athletes (24.7 ± 4.5 years) with GI issues (GI group at baseline, GI-B) and 21 athletes (25.4 ± 5.3 years) without GI issues (non-GI group, NGI) were included. At baseline, there was a significant difference in the total gastrointestinal symptom rating scale (GSRS) score (24.1 ± 8.48 vs. 30.3 ± 8.82, p = 0.008) and a trend difference in PHQ (33.9 ± 10.7 vs. 30.3 ± 8.82, p = 0.081), but no differences (p > 0.05) were seen for other outcomes, including gut microbiota metrics, between groups. After 3-week supplementation, the GI group (GI-S) showed increased Bifidobacterium relative abundance (p < 0.05), reported a lower number of severe GI complaints (from 72% to 54%, p < 0.001), and PHQ declined (p = 0.010). In conclusion, well-trained athletes with GI complaints reported more severe GI symptoms than an athletic reference group, without showing clear differences in wellbeing or microbiota composition. Future controlled research should further investigate the impact of such multi-ingredient supplements on GI complaints and the associated changes in gut health-related markers.
摘要：
目前的文献缺乏明确的胃肠道（GI）症状的表征，肠道菌群组成，以及训练有素的运动员的总体身心健康。因此,这项研究旨在描述自我报告症状的差异，肠道菌群组成，和福祉(即，睡眠质量,心情,以及有和没有胃肠道症状的运动员之间的身体（PHQ）和心理健康）。此外,我们评估了胃肠道投诉组中3周多成分发酵乳清补充剂的潜在影响，没有对照组，关于肠道微生物群和自我报告的胃肠道症状和健康状况。共有50名运动员（24.7±4.5岁）患有胃肠道问题（基线时的胃肠道组，GI-B）和21名没有GI问题的运动员（25.4±5.3岁）（非GI组，NGI）包括在内。在基线,总胃肠道症状评定量表（GSRS）评分存在显着差异（24.1±8.48vs.30.3±8.82，p=0.008）和PHQ的趋势差异（33.9±10.7与30.3±8.82，p=0.081），但其他结局没有差异(p>0.05)，包括肠道微生物群指标，群体之间。补充3周后，GI组（GI-S）显示双歧杆菌相对丰度增加（p<0.05），报告的严重胃肠道投诉数量较低(从72%到54%，p<0.001)，PHQ下降(p=0.010)。总之,受过良好训练的有胃肠道主诉的运动员报告的胃肠道症状比运动参考组更严重，在健康或微生物组成方面没有明显差异。未来的对照研究应该进一步调查这种多成分补充剂对胃肠道疾病的影响以及肠道健康相关标志物的相关变化。
