PDF(Pubmed)
Abstract：
Rice bean [Vigna umbellata (Thunb.) Ohwi and Ohashi], an annual legume in the genus Vigna, is a promising crop suitable for cultivation in a changing climate to ensure food security. It is also a medicinal plant widely used in traditional Chinese medicine; however, little is known about the medicinal compounds in rice bean. In this study, we assessed the diuretic effect of rice bean extracts on mice as well as its relationship with the contents of eight secondary metabolites in seeds. Mice gavaged with rice bean extracts from yellow and black seeds had higher urinary output (5.44-5.47 g) and water intake (5.8-6.3 g) values than mice gavaged with rice bean extracts from red seeds. Correlation analyses revealed significant negative correlations between urine output and gallic acid (R = -0.70) and genistein (R = -0.75) concentrations, suggesting that these two polyphenols negatively regulate diuresis. There were no obvious relationships between mice diuresis-related indices (urine output, water intake, and weight loss) and rutin or catechin contents, although the concentrations of both of these polyphenols in rice bean seeds were higher than the concentrations of the other six secondary metabolites. Our study findings may be useful for future research on the diuretic effects of rice bean, but they should be confirmed on the basis of systematic medical trials.
摘要：
米豆[Vignaumbellata(Thunb.)Ohwi和Ohashi],Vigna属的一年生豆科植物，是一种有前途的作物，适合在不断变化的气候下种植，以确保粮食安全。它也是一种广泛用于中药的药用植物；然而，人们对米豆中的药用化合物知之甚少。在这项研究中,我们评估了米豆提取物对小鼠的利尿作用及其与种子中8种次生代谢产物含量的关系。与用红色种子的米豆提取物灌胃的小鼠相比，用黄色和黑色种子的米豆提取物灌胃的小鼠的排尿量（5.44-5.47g）和饮水量（5.8-6.3g）更高。相关分析显示，尿量与没食子酸（R=-0.70）和金雀异黄素（R=-0.75）浓度之间呈显著负相关，表明这两种多酚对利尿有负调节作用。小鼠利尿相关指标(尿量，取水,和体重减轻）和芦丁或儿茶素含量，尽管这两种多酚在稻豆种子中的浓度均高于其他六种次生代谢产物的浓度。我们的研究结果可能有助于未来研究稻豆的利尿作用，但是它们应该在系统的医学试验的基础上得到证实。
