PDF(Pubmed)
Abstract：
According to data from the World Health Organization (WHO), cancer is considered to be one of the leading causes of death worldwide, and new therapeutic approaches, especially improved novel cancer treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend to have poor pharmacokinetic profiles, including rapid clearance and limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead to remarkable improvements. This is confirmed by an increasing number of papers in this field, showing that the on-target peptide functionalization of magnetic nanoparticles improves their penetration properties and ensures tumor-specific binding, which results in an increased clinical response. This review aims to highlight the potential applications of THPs in combination with magnetic carriers across various fields, including a pharmacoeconomic perspective.
摘要：
根据世界卫生组织（WHO）的数据，癌症被认为是全球死亡的主要原因之一，和新的治疗方法，特别是改进的新型癌症治疗方案，需求很高。考虑到许多化疗药物往往具有较差的药代动力学特征，包括快速清除和有限的现场积累，与肿瘤归巢肽(THP)功能化磁性纳米颗粒联合使用的方法可能会带来显著的改善.这一领域越来越多的论文证实了这一点，表明磁性纳米颗粒的靶肽功能化改善了它们的渗透性能，并确保了肿瘤特异性结合，导致临床反应增加。这篇综述旨在强调THP与磁性载体结合在各个领域的潜在应用，包括药物经济学的观点。
