PDF(Pubmed)
Abstract：
Insects have developed sophisticated detoxification systems to protect them from plant secondary metabolites while feeding on plants to obtain necessary nutrients. As an important enzyme in the system, glycosyltransferase 1 (GT1) conjugates toxic compounds to mitigate their harm to insects. However, the evolutionary link between GT1s and insect plant feeding remains elusive. In this study, we explored the evolution of GT1s across different insect orders and feeding niches using publicly available insect genomes. GT1 is widely present in insect species; however, its gene number differs among insect orders. Notably, plant-sap-feeding species have the highest GT1 gene numbers, whereas blood-feeding species display the lowest. GT1s appear to be associated with insect adaptations to different plant substrates in different orders, while the shift to non-plant feeding is related to several losses of GT1s. Most large gene numbers are likely the consequence of tandem duplications showing variations in collinearity among insect orders. These results reveal the potential relationships between the evolution of GT1s and insect adaptation to plant feeding, facilitating our understanding of the molecular mechanisms underlying insect-plant interactions.
摘要：
昆虫已经开发出复杂的解毒系统，以保护它们免受植物次生代谢产物的侵害，同时以植物为食以获得必要的营养。作为系统中的重要酶，糖基转移酶1（GT1）偶联有毒化合物以减轻其对昆虫的伤害。然而,GT1与昆虫植物摄食之间的进化联系仍然难以捉摸。在这项研究中,我们使用公开的昆虫基因组探索了GT1在不同昆虫顺序和摄食位的进化。GT1广泛存在于昆虫物种中；然而，它的基因数量因昆虫不同而不同。值得注意的是,植物树液饲喂物种具有最高的GT1基因数量，而采血物种显示最低。GT1似乎与昆虫以不同的顺序适应不同的植物基质有关，而向非植物饲喂的转变与GT1的若干损失有关。大多数大的基因数量可能是串联重复的结果，表明昆虫顺序之间的共线性变化。这些结果揭示了GT1的进化与昆虫对植物摄食的适应之间的潜在关系，促进我们对昆虫-植物相互作用的分子机制的理解。
