PDF(Pubmed)
Abstract：
Inulin, a natural polysaccharide, has emerged as a promising precursor for the preparation of hydrogels due to its biocompatibility, biodegradability, and structural versatility. This review provides a comprehensive overview of the recent progress in the preparation, characterization, and diverse applications of inulin-based hydrogels. Different synthesis strategies, including physical methods (thermal induction and non-thermal induction), chemical methods (free-radical polymerization and chemical crosslinking), and enzymatic approaches, are discussed in detail. The unique properties of inulin-based hydrogels, such as stimuli-responsiveness, antibacterial activity, and their potential as fat replacers, are highlighted. Special emphasis is given to their promising applications in drug delivery systems, especially for colon-targeted delivery, due to the selective degradation of inulin via colonic microflora. The ability to incorporate both hydrophilic and hydrophobic drugs further expands their therapeutic potential. In addition, the applications of inulin-based hydrogels in responsive materials, the food industry, wound dressings, and tissue engineering are discussed. While significant progress has been achieved, challenges and prospects in optimizing synthesis, improving mechanical properties, and exploring new functionalities are discussed. Overall, this review highlights the remarkable properties of inulin-based hydrogels as a promising class of biomaterials with immense potential in the biomedical, pharmaceutical, and materials science fields.
摘要：
菊粉,一种天然多糖，由于其生物相容性，已成为制备水凝胶的有希望的前体，生物降解性，和结构的多功能性。这篇综述全面概述了近期的编制工作进展,表征，菊粉基水凝胶的不同应用。不同的合成策略，包括物理方法（热感应和非热感应），化学方法（自由基聚合和化学交联），和酶方法，详细讨论。菊粉基水凝胶的独特性能，如刺激反应，抗菌活性，以及他们作为脂肪替代品的潜力，被突出显示。特别强调它们在药物递送系统中的有希望的应用，特别是结肠靶向给药,由于菊粉通过结肠微生物区系的选择性降解。结合亲水性和疏水性药物的能力进一步扩展了它们的治疗潜力。此外,菊粉基水凝胶在响应材料中的应用，食品工业,伤口敷料,和组织工程进行了讨论。虽然取得了重大进展，优化合成的挑战和前景，改善机械性能，并对探索新功能进行了讨论。总的来说,这篇综述强调了菊粉基水凝胶作为一类有前途的生物材料的显着特性，在生物医学中具有巨大的潜力，Pharmaceutical,和材料科学领域。
