PDF(Pubmed)
Abstract：
BACKGROUND: Patients with heart failure with preserved ejection fraction (HFpEF) commonly experience exercise intolerance, resulting in reduced cardiorespiratory fitness. This is characterised by a decreased maximal oxygen uptake (V̇O2peak), which is determined by the product of cardiac output (CO) and arteriovenous oxygen difference (a-vDO2). While exercise training has been shown to improve V̇O2peak in HFpEF patients, the effects on CO remain unclear. The aim of this study is to systematically review and analyse the current evidence on the effects of supervised exercise training on CO in patients with HFpEF.
METHODS: We will systematically search for literature describing the effects of supervised exercise training on CO in patients with HFpEF. All eligible studies published before 30 June 2023 in the following electronic databases will be included: MEDLINE (Ovid), Embase (Ovid), SPORTDiscus (EBSCOhost), and CENTRAL (Cochrane Library). Effect sizes will be extracted for CO before and after a supervised exercise training intervention at rest and maximal exercise. Mass of heterogeneity (I2) will be calculated, and either fixed-effect models or random-effect models will be used for meta-analysis. To detect a potential publication bias, funnel plot analyses will be performed.
CONCLUSIONS: While several studies have reported a positive effect of supervised exercise training on cardiorespiratory fitness, attempts to assess the underlying determinants of V̇O2peak, CO, and a-vDO2 are much scarcer, especially in patients with HFpEF. From a physiological perspective, measuring CO before and after supervised exercise training seems to be a reasonable way to accurately operationalise a potential improvement in cardiac function.
BACKGROUND: PROSPERO CRD42022361485.
METHODS: We will systematically search for literature describing the effects of supervised exercise training on CO in patients with HFpEF. All eligible studies published before 30 June 2023 in the following electronic databases will be included: MEDLINE (Ovid), Embase (Ovid), SPORTDiscus (EBSCOhost), and CENTRAL (Cochrane Library). Effect sizes will be extracted for CO before and after a supervised exercise training intervention at rest and maximal exercise. Mass of heterogeneity (I2) will be calculated, and either fixed-effect models or random-effect models will be used for meta-analysis. To detect a potential publication bias, funnel plot analyses will be performed.
CONCLUSIONS: While several studies have reported a positive effect of supervised exercise training on cardiorespiratory fitness, attempts to assess the underlying determinants of V̇O2peak, CO, and a-vDO2 are much scarcer, especially in patients with HFpEF. From a physiological perspective, measuring CO before and after supervised exercise training seems to be a reasonable way to accurately operationalise a potential improvement in cardiac function.
BACKGROUND: PROSPERO CRD42022361485.
摘要：
背景：射血分数保留（HFpEF）的心力衰竭患者通常会出现运动不耐受，导致心肺健康下降。其特征是最大摄氧量降低（V♪O2峰），其由心输出量(CO)和动静脉氧差(a-vDO2)的乘积确定。虽然运动训练已被证明可以改善HFpEF患者的V²O2peak，对CO的影响尚不清楚。这项研究的目的是系统地回顾和分析有关有监督的运动训练对HFpEF患者CO影响的当前证据。
方法：我们将系统地搜索描述有监督运动训练对HFpEF患者CO影响的文献。在2023年6月30日之前在以下电子数据库中发布的所有符合条件的研究都将包括：MEDLINE（Ovid），Embase(Ovid),SPORTDiscus(EBSCOhost),和CENTRAL（Cochrane图书馆）。在休息和最大运动时进行监督运动训练干预之前和之后，将提取CO的效果大小。将计算异质性质量(I2)，固定效应模型或随机效应模型将用于荟萃分析。为了检测潜在的出版偏见，将进行漏斗图分析。
结论：虽然一些研究报告了有监督的运动训练对心肺健康的积极影响，试图评估V²O2peak的潜在决定因素，CO,而且a-vDO2要稀缺得多，尤其是HFpEF患者。从生理的角度来看,在有监督的运动训练之前和之后测量CO似乎是准确操作心脏功能潜在改善的合理方法。
背景：PROSPEROCRD42022361485。
方法：我们将系统地搜索描述有监督运动训练对HFpEF患者CO影响的文献。在2023年6月30日之前在以下电子数据库中发布的所有符合条件的研究都将包括：MEDLINE（Ovid），Embase(Ovid),SPORTDiscus(EBSCOhost),和CENTRAL（Cochrane图书馆）。在休息和最大运动时进行监督运动训练干预之前和之后，将提取CO的效果大小。将计算异质性质量(I2)，固定效应模型或随机效应模型将用于荟萃分析。为了检测潜在的出版偏见，将进行漏斗图分析。
结论：虽然一些研究报告了有监督的运动训练对心肺健康的积极影响，试图评估V²O2peak的潜在决定因素，CO,而且a-vDO2要稀缺得多，尤其是HFpEF患者。从生理的角度来看,在有监督的运动训练之前和之后测量CO似乎是准确操作心脏功能潜在改善的合理方法。
背景：PROSPEROCRD42022361485。
