PDF(Pubmed)
Abstract：
The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This review discusses the utilization of nanomaterial-assisted gene editing tools and synthetic biology techniques to promote the development of more precise and efficient treatments for pulmonary diseases. First, we briefly outline the characterization of the respiratory system and succinctly describe the principal applications of diverse nanomaterials in lung ailment treatment. Second, we elaborate on gene-editing tools, their configurations, and assorted delivery methods, while delving into the present state of nanomaterial-facilitated gene-editing interventions for a spectrum of pulmonary diseases. Subsequently, we briefly expound on synthetic biology and its deployment in biomedicine, focusing on research advances in the diagnosis and treatment of pulmonary conditions against the backdrop of the coronavirus disease 2019 pandemic. Finally, we summarize the extant lacunae in current research and delineate prospects for advancement in this domain. This holistic approach augments the development of pioneering solutions in lung disease treatment, thereby endowing patients with more efficacious and personalized therapeutic alternatives.
摘要：
在基因编辑和合成生物学中使用纳米材料已成为追求肺部疾病的精细治疗方法的关键策略。本文综述了利用纳米材料辅助的基因编辑工具和合成生物学技术来促进更精确和有效的肺部疾病治疗方法的发展。首先,我们简要概述了呼吸系统的特征，并简要描述了各种纳米材料在肺部疾病治疗中的主要应用。第二,我们详细阐述基因编辑工具，他们的配置，和各种交付方法，同时深入研究纳米材料促进的基因编辑干预对一系列肺部疾病的现状。随后，我们简要阐述了合成生物学及其在生物医学中的应用，重点关注2019年冠状病毒大流行背景下肺部疾病诊断和治疗的研究进展。最后,我们总结了现有的lacunae在当前的研究，并描述了该领域的发展前景。这种整体方法促进了肺部疾病治疗开创性解决方案的发展，从而赋予患者更有效和个性化的治疗选择。
