PDF(Pubmed)
Abstract：
BACKGROUND: One of the most prevalent health problems affecting children worldwide is untreated caries in primary teeth. Agents to arrest caries are used to manage untreated decay in children in disadvantaged communities. Nano Silver Fluoride (NSF) overcomes the staining problems of Silver Diamine Fluoride (SDF). This study compared the clinical cariostatic effect of NSF to 38% SDF for arresting caries lesions.
METHODS: The study included 360 children younger than 4 years, with at least one active lesion, ICDAS score ≥ 3, recruited from nurseries in a rural area in Alexandria, Egypt, in 2022. They were randomly assigned to receive a single application of NSF at baseline, or two applications of SDF at baseline and after 6 months. The arrest of active carious lesions was assessed after 6 and 12 months using ICDAS criteria, and parents\' satisfaction with child appearance was also assessed. Chi-Square test was used to compare the groups and multi-level multiple logistic regression was used to assess the effect of the intervention on caries arrest at lesion level and binary logistic regression was used to assess the effect at patient level.
RESULTS: 1853 active lesions were included in children whose mean (SD) age was 42.3 (8.2) months. The arrest rate was significantly higher in the NSF than the SDF group at lesion level (78.4% and 65.0% at 6 months and 71.3% and 56.3% at 12 months, p < 0.001). In regression analysis, NSF had significantly higher odds of caries arrest than SDF at lesion level (at 6 months, AOR = 2.57, 95% CI: 1.55, 4.26 and at 12 month, AOR = 3.27, 95% CI: 1.89, 5.67). Parents of children receiving NSF had significantly greater satisfaction with their children\'s dental appearance than those receiving SDF: (97.2% and 76.1%, respectively, p < 0.001).
CONCLUSIONS: NSF demonstrated greater effectiveness in arresting caries in preschool children without inducing black staining of teeth and with greater parental satisfaction than SDF. NSF can be an alternative to SDF in arresting caries especially in underprivileged communities.
BACKGROUND: The trial was registered in the clinicaltrials.gov registry (#NCT05255913)-16/02/2022.
METHODS: The study included 360 children younger than 4 years, with at least one active lesion, ICDAS score ≥ 3, recruited from nurseries in a rural area in Alexandria, Egypt, in 2022. They were randomly assigned to receive a single application of NSF at baseline, or two applications of SDF at baseline and after 6 months. The arrest of active carious lesions was assessed after 6 and 12 months using ICDAS criteria, and parents\' satisfaction with child appearance was also assessed. Chi-Square test was used to compare the groups and multi-level multiple logistic regression was used to assess the effect of the intervention on caries arrest at lesion level and binary logistic regression was used to assess the effect at patient level.
RESULTS: 1853 active lesions were included in children whose mean (SD) age was 42.3 (8.2) months. The arrest rate was significantly higher in the NSF than the SDF group at lesion level (78.4% and 65.0% at 6 months and 71.3% and 56.3% at 12 months, p < 0.001). In regression analysis, NSF had significantly higher odds of caries arrest than SDF at lesion level (at 6 months, AOR = 2.57, 95% CI: 1.55, 4.26 and at 12 month, AOR = 3.27, 95% CI: 1.89, 5.67). Parents of children receiving NSF had significantly greater satisfaction with their children\'s dental appearance than those receiving SDF: (97.2% and 76.1%, respectively, p < 0.001).
CONCLUSIONS: NSF demonstrated greater effectiveness in arresting caries in preschool children without inducing black staining of teeth and with greater parental satisfaction than SDF. NSF can be an alternative to SDF in arresting caries especially in underprivileged communities.
BACKGROUND: The trial was registered in the clinicaltrials.gov registry (#NCT05255913)-16/02/2022.
摘要：
背景：影响全世界儿童的最普遍的健康问题之一是乳牙中未经治疗的龋齿。阻止龋齿的代理商用于管理弱势社区儿童未经治疗的腐烂。纳米氟化银(NSF)克服了氟化银二胺(SDF)的染色问题。这项研究比较了NSF与38％SDF的临床防龋效果，以阻止龋齿病变。
方法：这项研究包括360名4岁以下的儿童，至少有一个活动性病变，ICDAS评分≥3，从亚历山大农村地区的托儿所招募，埃及,2022年。他们被随机分配在基线时接受一次NSF申请，或在基线和6个月后两次应用SDF。在6个月和12个月后使用ICDAS标准评估活动性龋齿病变的停止。和父母对儿童外观的满意度也进行了评估。采用卡方检验比较各组,采用多水平多元logistic回归评估干预对病变水平龋齿阻滞的影响,采用二元logistic回归评估患者水平的影响。
结果：1853个活动性病变包括在平均（SD）年龄为42.3（8.2）个月的儿童中。NSF在病变水平上的停滞率明显高于SDF组（6个月时为78.4％和65.0％，12个月时为71.3％和56.3％，p<0.001)。在回归分析中，NSF在病变水平有明显高于SDF的龋齿停滞几率（6个月时，AOR=2.57，95%CI：1.55，4.26和12个月时，AOR=3.27，95%CI：1.89，5.67）。接受NSF的孩子的父母对孩子的牙齿外观的满意度明显高于接受SDF的孩子：（97.2％和76.1％，分别,p<0.001)。
结论：与SDF相比，NSF在阻止学龄前儿童龋齿方面表现出更高的有效性，而不会引起牙齿黑色染色，并且父母的满意度更高。NSF可以替代SDF，特别是在贫困社区中，可以逮捕龋齿。
背景：该试验已在clinicaltrials.gov注册表（＃NCT05255913）-2022年2月16日注册。
方法：这项研究包括360名4岁以下的儿童，至少有一个活动性病变，ICDAS评分≥3，从亚历山大农村地区的托儿所招募，埃及,2022年。他们被随机分配在基线时接受一次NSF申请，或在基线和6个月后两次应用SDF。在6个月和12个月后使用ICDAS标准评估活动性龋齿病变的停止。和父母对儿童外观的满意度也进行了评估。采用卡方检验比较各组,采用多水平多元logistic回归评估干预对病变水平龋齿阻滞的影响,采用二元logistic回归评估患者水平的影响。
结果：1853个活动性病变包括在平均（SD）年龄为42.3（8.2）个月的儿童中。NSF在病变水平上的停滞率明显高于SDF组（6个月时为78.4％和65.0％，12个月时为71.3％和56.3％，p<0.001)。在回归分析中，NSF在病变水平有明显高于SDF的龋齿停滞几率（6个月时，AOR=2.57，95%CI：1.55，4.26和12个月时，AOR=3.27，95%CI：1.89，5.67）。接受NSF的孩子的父母对孩子的牙齿外观的满意度明显高于接受SDF的孩子：（97.2％和76.1％，分别,p<0.001)。
结论：与SDF相比，NSF在阻止学龄前儿童龋齿方面表现出更高的有效性，而不会引起牙齿黑色染色，并且父母的满意度更高。NSF可以替代SDF，特别是在贫困社区中，可以逮捕龋齿。
背景：该试验已在clinicaltrials.gov注册表（＃NCT05255913）-2022年2月16日注册。
