PDF(Pubmed)
Abstract：
Diarrheal diseases are important causes of morbidity and mortality, worldwide. The occurrence of multiple pathogens in stool samples of symptomatic and asymptomatic individuals in resource-limited countries have been repeatedly described. In this study, we assessed the differentiated effects of combined pathogen detections on recorded symptoms. A case-control study was conducted among 620 under-five-year-old children in rural northeastern Tanzania with emphasis of multiple detection. The median age of children was 11 months (IQR = 7, 20), and 52.1% were male. Cases (50.2%, n = 157) were less likely than controls (64.5%, n = 198) to have multiple colonization with gastrointestinal tract (GIT) pathogens. The children\'s age was positively associated with the likelihood of harboring multiple GIT pathogens [OR, 1.02, 95% CI = 1.01, 1.04]. Shigella spp./enteroinvasive Escherichia coli (EIEC) [OR = 2.80, 95% CI 1.62, 4.83] and norovirus [OR = 2.04, 95% CI 1.23, 3.39] were more common in cases and were strongly associated with diarrhea, while enteroaggregative E. coli (EAEC) [OR = 0.23, 95%CI 0.17-0.33] were more common in controls. Diarrheal diseases in under-five children from rural Tanzania are likely to be due to infections with Shigella spp./EIEC, and norovirus with strongly age-dependent associations.
摘要：
腹泻病是发病率和死亡率的重要原因,全世界。在资源有限的国家中，有症状和无症状个体的粪便样本中多种病原体的发生已被反复描述。在这项研究中,我们评估了合并病原体检测对记录症状的差异效应.在坦桑尼亚东北部农村地区的620名五岁以下儿童中进行了病例对照研究，重点是多重检测。儿童的中位年龄为11个月（IQR=7,20），男性占52.1%。病例（50.2%，n=157)的可能性低于对照组(64.5%，n=198）具有胃肠道（GIT）病原体的多重定植。儿童的年龄与携带多种GIT病原体的可能性呈正相关[OR，1.02，95%CI=1.01，1.04]。志贺氏菌属。/肠侵袭性大肠杆菌（EIEC）[OR=2.80，95％CI1.62，4.83]和诺如病毒[OR=2.04，95％CI1.23，3.39]在病例中更为常见，并与腹泻密切相关，而肠聚集性大肠杆菌（EAEC）[OR=0.23，95CI0.17-0.33]在对照组中更常见。坦桑尼亚农村五岁以下儿童的腹泻病可能是由于志贺氏菌属感染所致。/EIEC,和诺如病毒具有强烈的年龄依赖性关联。
