PDF(Pubmed)
Abstract：
BACKGROUND: Vitiligo, a common dermatological disorder in Saudi Arabia, is associated with significant psychological impacts. This study explores the relationship between vitiligo and the severity of major depressive disorder (MDD), highlighting the broader implications on mental health among affected individuals.
OBJECTIVE: We aim to assess the prevalence and predictors of depression among adult patients with vitiligo, and to examine the relationship between MDD severity and vitiligo.
METHODS: Using a cross-sectional design, the research used the vitiligo area severity index and the Patient Health Questionnaire-9 to measure the extent of vitiligo and depression severity, respectively. This study involved 340 diagnosed patients with vitiligo from various health care settings. Logistic and ordinal regression analysis were applied to evaluate the impact of sociodemographic variables and vitiligo types on MDD severity.
RESULTS: The prevalence of MDD was 58.8% (200/340) of participants. Depression severity varied notably: 18.2% (62/340) of patients experienced mild depression, 17.9% (61/340) moderate, 11.8% (40/340) moderately severe, and 10.9% (37/340) severe depression. Female patients had higher odds of severe depression than male patients (adjusted odds ratio [aOR] 3.14, 95% CI 1.93-5.1; P<.001). Age was inversely related to depression severity, with patients aged older than 60 years showing significantly lower odds (aOR 0.1, 95% CI 0.03-0.39; P<.001). Lower income was associated with higher depression severity (aOR 10.2, 95% CI 3.25-31.8; P<.001). Vitiligo types also influenced depression severity; vulgaris (aOR 5.3, 95% CI 2.6-10.9; P<.001) and acrofacial vitiligo (aOR 2.8, 95% CI 1.5-5.1; P<.001) were significantly associated with higher depression levels compared to focal vitiligo.
CONCLUSIONS: The findings suggest that vitiligo contributes to an increased risk of severe depression, highlighting the need for integrated dermatological and psychological treatment approaches to address both the physical and mental health aspects of the disease.
OBJECTIVE: We aim to assess the prevalence and predictors of depression among adult patients with vitiligo, and to examine the relationship between MDD severity and vitiligo.
METHODS: Using a cross-sectional design, the research used the vitiligo area severity index and the Patient Health Questionnaire-9 to measure the extent of vitiligo and depression severity, respectively. This study involved 340 diagnosed patients with vitiligo from various health care settings. Logistic and ordinal regression analysis were applied to evaluate the impact of sociodemographic variables and vitiligo types on MDD severity.
RESULTS: The prevalence of MDD was 58.8% (200/340) of participants. Depression severity varied notably: 18.2% (62/340) of patients experienced mild depression, 17.9% (61/340) moderate, 11.8% (40/340) moderately severe, and 10.9% (37/340) severe depression. Female patients had higher odds of severe depression than male patients (adjusted odds ratio [aOR] 3.14, 95% CI 1.93-5.1; P<.001). Age was inversely related to depression severity, with patients aged older than 60 years showing significantly lower odds (aOR 0.1, 95% CI 0.03-0.39; P<.001). Lower income was associated with higher depression severity (aOR 10.2, 95% CI 3.25-31.8; P<.001). Vitiligo types also influenced depression severity; vulgaris (aOR 5.3, 95% CI 2.6-10.9; P<.001) and acrofacial vitiligo (aOR 2.8, 95% CI 1.5-5.1; P<.001) were significantly associated with higher depression levels compared to focal vitiligo.
CONCLUSIONS: The findings suggest that vitiligo contributes to an increased risk of severe depression, highlighting the need for integrated dermatological and psychological treatment approaches to address both the physical and mental health aspects of the disease.
摘要：
背景：白癜风，沙特阿拉伯常见的皮肤病，与重大的心理影响有关。本研究探讨白癜风与重度抑郁症(MDD)严重程度的关系,强调受影响个体对心理健康的更广泛影响。
目的：评估成人白癜风患者抑郁症的患病率和预测因素，并探讨MDD严重程度与白癜风的关系。
方法：采用横截面设计，该研究利用白癜风地区严重程度指数（VASI）和患者健康问卷-9（PHQ-9）分别测量白癜风和抑郁严重程度。该研究涉及来自各种医疗机构的340名诊断为白癜风的患者。Logistic和序数回归分析用于评估社会人口统计学变量和白癜风类型对MDD严重程度的影响。
结果：MDD的患病率为58.8％（340名参与者中有200名）。抑郁严重程度差异显著：24.7%的患者经历轻度抑郁，31.1%中度，22.6％中度重度，和21.6%的严重抑郁症。女性患者患重度抑郁症的几率高于男性(aOR=3.14,95%CI:1.93-5.1,P<.001)。年龄与抑郁严重程度成反比，60岁以上患者的几率显着降低（aOR=0.1，95％CI：0.03-0.39，P<.001）。较低的收入与较高的抑郁严重程度相关(aOR=10.2,95%CI:3.25-31.8,P<.001)。白癜风类型也影响抑郁严重程度；寻常型（aOR=5.3，95％CI：2.6-10.9，P<.001）和肩面型白癜风（aOR=2.8，95％CI：1.5-5.1，P<.001）与较高的抑郁水平显着相关。
结论：研究结果表明，白癜风导致严重抑郁症的风险增加，强调需要综合的皮肤病和心理治疗方法，以解决疾病的身体和心理健康方面。
背景：
目的：评估成人白癜风患者抑郁症的患病率和预测因素，并探讨MDD严重程度与白癜风的关系。
方法：采用横截面设计，该研究利用白癜风地区严重程度指数（VASI）和患者健康问卷-9（PHQ-9）分别测量白癜风和抑郁严重程度。该研究涉及来自各种医疗机构的340名诊断为白癜风的患者。Logistic和序数回归分析用于评估社会人口统计学变量和白癜风类型对MDD严重程度的影响。
结果：MDD的患病率为58.8％（340名参与者中有200名）。抑郁严重程度差异显著：24.7%的患者经历轻度抑郁，31.1%中度，22.6％中度重度，和21.6%的严重抑郁症。女性患者患重度抑郁症的几率高于男性(aOR=3.14,95%CI:1.93-5.1,P<.001)。年龄与抑郁严重程度成反比，60岁以上患者的几率显着降低（aOR=0.1，95％CI：0.03-0.39，P<.001）。较低的收入与较高的抑郁严重程度相关(aOR=10.2,95%CI:3.25-31.8,P<.001)。白癜风类型也影响抑郁严重程度；寻常型（aOR=5.3，95％CI：2.6-10.9，P<.001）和肩面型白癜风（aOR=2.8，95％CI：1.5-5.1，P<.001）与较高的抑郁水平显着相关。
结论：研究结果表明，白癜风导致严重抑郁症的风险增加，强调需要综合的皮肤病和心理治疗方法，以解决疾病的身体和心理健康方面。
背景：
