Abstract：
Chetocochliodin M (5) containing a rare cage-ring and chetocochliodin N (6) featuring an unusual piperazine-2,3-dione ring system together with known analogues chetomin (1), chetoseminudin C (2), chetocochliodin I (3), and oidioperazine E (4) were targeted for purification from the fungus Chaetomium cochliodes using a UPLC-Q-TOF-MS/MS approach. The structures of the new compounds were elucidated using HR-ESI-MS, NMR, and ECD spectra. Compounds 1, 3, and 6 exhibited strong cytotoxic activities against A549 and HeLa cancer cell lines.
摘要：
ChetocochiodinJ（5）含有罕见的笼环和chetocochiodinK（6），具有不寻常的哌嗪-2,3-二酮环系统以及已知的类似物chetomin（1），尿嘧啶C（2），chetocochiodinI（3），使用UPLC-Q-TOF-MS/MS方法，将idiperazineE（4）和oidiperazineE（4）用于从真菌耳蜗毛虫中纯化。使用HR-ESI-MS阐明了新化合物的结构，NMR,和ECD光谱。化合物1、3和6对A549和HeLa癌细胞系表现出强的细胞毒活性。
