%0 Journal Article
%T UPLC-Q-TOF-MS/MS-Based Targeted Discovery of Chetomin Analogues from Chaetomium cochliodes.
%A Liu JZ
%A Wang YD
%A Fang HQ
%A Sun GB
%A Ding G
%J J Nat Prod
%V 87
%N 6
%D 2024 Jun 28
%M 38888514
%F 4.803
%R 10.1021/acs.jnatprod.4c00215
%X Chetocochliodin M (5) containing a rare cage-ring and chetocochliodin N (6) featuring an unusual piperazine-2,3-dione ring system together with known analogues chetomin (1), chetoseminudin C (2), chetocochliodin I (3), and oidioperazine E (4) were targeted for purification from the fungus Chaetomium cochliodes using a UPLC-Q-TOF-MS/MS approach. The structures of the new compounds were elucidated using HR-ESI-MS, NMR, and ECD spectra. Compounds 1, 3, and 6 exhibited strong cytotoxic activities against A549 and HeLa cancer cell lines.