{Reference Type}: Journal Article
{Title}: UPLC-Q-TOF-MS/MS-Based Targeted Discovery of Chetomin Analogues from Chaetomium cochliodes.
{Author}: Liu JZ;Wang YD;Fang HQ;Sun GB;Ding G;
{Journal}: J Nat Prod
{Volume}: 87
{Issue}: 6
{Year}: 2024 Jun 28
{Factor}: 4.803
{DOI}: 10.1021/acs.jnatprod.4c00215
{Abstract}: Chetocochliodin M (5) containing a rare cage-ring and chetocochliodin N (6) featuring an unusual piperazine-2,3-dione ring system together with known analogues chetomin (1), chetoseminudin C (2), chetocochliodin I (3), and oidioperazine E (4) were targeted for purification from the fungus Chaetomium cochliodes using a UPLC-Q-TOF-MS/MS approach. The structures of the new compounds were elucidated using HR-ESI-MS, NMR, and ECD spectra. Compounds 1, 3, and 6 exhibited strong cytotoxic activities against A549 and HeLa cancer cell lines.