PDF(Pubmed)
Abstract：
BACKGROUND: Dilatation of common bile duct (CBD) is mostly pathological and mainly occurs secondary to mechanical causes. We aimed to explore the prevalence of CBD dilatation in Intraductal Papillary Mucinous Neoplasms of the pancreas (IPMN) among patients referred to EUS.
METHODS: A retrospective study of all patients who had an EUS diagnosis of IPMN from 2011 to 2019 at Galilee Medical Center were extracted. Control group including patients with other types of pancreatic cysts.
RESULTS: Overall, 2400 patients were included in the study, of them 158 patients were diagnosed with pancreatic cysts, 117 patients (74%) diagnosed with IPMN (group A), and 41 patients (26%) diagnosed with other pancreatic cysts (group B). Univariate analysis showed significant association of IPMN (OR 3.8, 95% CI 1.3-11.5), resected gallbladder (GB) (OR 7.75, 95% CI 3.19-18.84), and age (OR 1, 95% CI 1.01-1.08) with CBD dilatation. Classifying IPMN to sub-groups using adjusted multivariate logistic regression analysis, only main duct-IPMN (MD-IPMN) significantly correlated with CBD dilatation compared to branch duct (BD)-IPMN and mixed type-IPMN (OR 19.6, 95% CI 4.57-83.33, OR 16.3, 95% CI 3.02-88.08).
CONCLUSIONS: MD-IPMN was significantly correlated with dilated CBD. Assessment of the pancreas is warranted in encountered cases of dilated CBD without obvious mechanical cause.
METHODS: A retrospective study of all patients who had an EUS diagnosis of IPMN from 2011 to 2019 at Galilee Medical Center were extracted. Control group including patients with other types of pancreatic cysts.
RESULTS: Overall, 2400 patients were included in the study, of them 158 patients were diagnosed with pancreatic cysts, 117 patients (74%) diagnosed with IPMN (group A), and 41 patients (26%) diagnosed with other pancreatic cysts (group B). Univariate analysis showed significant association of IPMN (OR 3.8, 95% CI 1.3-11.5), resected gallbladder (GB) (OR 7.75, 95% CI 3.19-18.84), and age (OR 1, 95% CI 1.01-1.08) with CBD dilatation. Classifying IPMN to sub-groups using adjusted multivariate logistic regression analysis, only main duct-IPMN (MD-IPMN) significantly correlated with CBD dilatation compared to branch duct (BD)-IPMN and mixed type-IPMN (OR 19.6, 95% CI 4.57-83.33, OR 16.3, 95% CI 3.02-88.08).
CONCLUSIONS: MD-IPMN was significantly correlated with dilated CBD. Assessment of the pancreas is warranted in encountered cases of dilated CBD without obvious mechanical cause.
摘要：
背景：胆总管（CBD）的扩张主要是病理性的，主要是继发于机械原因。我们旨在探讨在EUS患者中，胰腺导管内乳头状黏液性肿瘤（IPMN）中CBD扩张的患病率。
方法：提取2011年至2019年在加利利医学中心进行EUS诊断为IPMN的所有患者的回顾性研究。对照组包括其他类型胰腺囊肿患者。
结果：总体而言，2400名患者被纳入研究，其中158例患者被诊断为胰腺囊肿，117例（74%）诊断为IPMN（A组），41例（26%）诊断为其他胰腺囊肿（B组）。单因素分析显示IPMN显著相关(OR3.8，95%CI1.3-11.5)，切除的胆囊（GB）（OR7.75，95％CI3.19-18.84），CBD扩张的年龄(OR1，95%CI1.01-1.08)。使用调整后的多变量逻辑回归分析将IPMN分为亚组，与分支导管（BD）-IPMN和混合型IPMN相比，只有主管IPMN（MD-IPMN）与CBD扩张显着相关（OR19.6，95％CI4.57-83.33，OR16.3，95％CI3.02-88.08）。
结论：MD-IPMN与CBD扩张显著相关。在遇到没有明显机械原因的CBD扩张病例时，需要对胰腺进行评估。
方法：提取2011年至2019年在加利利医学中心进行EUS诊断为IPMN的所有患者的回顾性研究。对照组包括其他类型胰腺囊肿患者。
结果：总体而言，2400名患者被纳入研究，其中158例患者被诊断为胰腺囊肿，117例（74%）诊断为IPMN（A组），41例（26%）诊断为其他胰腺囊肿（B组）。单因素分析显示IPMN显著相关(OR3.8，95%CI1.3-11.5)，切除的胆囊（GB）（OR7.75，95％CI3.19-18.84），CBD扩张的年龄(OR1，95%CI1.01-1.08)。使用调整后的多变量逻辑回归分析将IPMN分为亚组，与分支导管（BD）-IPMN和混合型IPMN相比，只有主管IPMN（MD-IPMN）与CBD扩张显着相关（OR19.6，95％CI4.57-83.33，OR16.3，95％CI3.02-88.08）。
结论：MD-IPMN与CBD扩张显著相关。在遇到没有明显机械原因的CBD扩张病例时，需要对胰腺进行评估。
