Abstract：
Tissue repair and regeneration, such as bone and nerve restoration, face significant challenges due to strict regulations within the immune microenvironment, stem cell differentiation, and key cell behaviors. The development of 3D scaffolds is identified as a promising approach to address these issues via the efficiently structural regulations on cell fates and behaviors. In particular, 3D-printed polymer scaffolds with diverse micro-/nanostructures offer a great potential for mimicking the structures of tissue. Consequently, they are foreseen as promissing pathways for regulating cell fates, including cell phenotype, differentiation of stem cells, as well as the migration and the proliferation of key cells, thereby facilitating tissue repairs and regenerations. Herein, the roles of structural functions of 3D-printed polymer scaffolds in regulating the fates and behaviors of numerous cells related to tissue repair and regeneration, along with their specific influences are highlighted. Additionally, the challenges and outlooks associated with 3D-printed polymer scaffolds with various structures for modulating cell fates are also discussed.
摘要：
组织修复和再生，比如骨骼和神经修复，由于免疫微环境内的监管有限，遇到了重大挑战，干细胞分化，和关键细胞行为。3D支架已被确定为通过对细胞命运和行为的有效结构调节来解决这些问题的有希望的方法。特别是,具有不同微/纳米结构的3D打印聚合物支架为模拟组织结构提供了巨大的潜力。可以有效调节细胞命运，包括细胞表型，干细胞分化，以及促进组织修复和再生的关键细胞的迁移和增殖。在这里，3D打印聚合物支架的结构功能在调节与组织修复和再生相关的众多细胞的命运和行为中的作用，以及它们的具体影响被强调。此外,还讨论了与具有调节细胞命运的各种结构的3D打印聚合物支架相关的挑战和前景。本文受版权保护。保留所有权利。
