PDF(Pubmed)
Abstract：
OBJECTIVE: Modernization and Westernization in industrialized and developing nations is associated with a substantial increase in chronic noncommunicable diseases. This transformation has far-reaching effects on lifestyles, impacting areas such as economics, politics, social life, and culture, all of which, in turn, have diverse influences on public health. Loss of contact with nature, alternations in the microbiota, processed food consumption, exposure to environmental pollutants including chemicals, increased stress and decreased physical activity jointly result in increases in the frequency of inflammatory disorders including allergies and many autoimmune and neuropsychiatric diseases. This review aims to investigate the relationship between Western lifestyle and inflammatory disorders.
RESULTS: Several hypotheses have been put forth trying to explain the observed increases in these diseases, such as \'Hygiene Hypothesis\', \'Old Friends\', and \'Biodiversity and Dysbiosis\'. The recently introduced \'Epithelial Barrier Theory\' incorporates these former hypotheses and suggests that toxic substances in cleaning agents, laundry and dishwasher detergents, shampoos, toothpastes, as well as microplastic, packaged food and air pollution damage the epithelium of our skin, lungs and gastrointestinal system. Epithelial barrier disruption leads to decreased biodiversity of the microbiome and the development of opportunistic pathogen colonization, which upon interaction with the immune system, initiates local and systemic inflammation. Gaining a deeper comprehension of the interplay between the environment, microbiome and the immune system provides the data to assist with legally regulating the usage of toxic substances, to enable nontoxic alternatives and to mitigate these environmental challenges essential for fostering a harmonious and healthy global environment.
RESULTS: Several hypotheses have been put forth trying to explain the observed increases in these diseases, such as \'Hygiene Hypothesis\', \'Old Friends\', and \'Biodiversity and Dysbiosis\'. The recently introduced \'Epithelial Barrier Theory\' incorporates these former hypotheses and suggests that toxic substances in cleaning agents, laundry and dishwasher detergents, shampoos, toothpastes, as well as microplastic, packaged food and air pollution damage the epithelium of our skin, lungs and gastrointestinal system. Epithelial barrier disruption leads to decreased biodiversity of the microbiome and the development of opportunistic pathogen colonization, which upon interaction with the immune system, initiates local and systemic inflammation. Gaining a deeper comprehension of the interplay between the environment, microbiome and the immune system provides the data to assist with legally regulating the usage of toxic substances, to enable nontoxic alternatives and to mitigate these environmental challenges essential for fostering a harmonious and healthy global environment.
摘要：
目标：工业化国家和发展中国家的现代化和西方化与慢性非传染性疾病的大幅增加有关。这种转变对生活方式产生了深远的影响,影响经济等领域，政治,社会生活,和文化,所有这些,反过来,对公众健康有不同的影响。失去与大自然的接触，微生物群的交替，加工食品消费，暴露于环境污染物，包括化学品，增加的压力和减少的体力活动共同导致增加的频率的炎症性疾病，包括过敏和许多自身免疫和神经精神疾病。本文旨在探讨西方生活方式与炎症性疾病之间的关系。
结果：已经提出了一些假设，试图解释观察到的这些疾病的增加，如“卫生假说”，\'老朋友\',和“生物多样性和菌群失调”。最近引入的“上皮屏障理论”包含了这些以前的假设，并表明清洁剂中的有毒物质，洗衣和洗碗机洗涤剂，洗发水,牙膏,以及微塑料，包装食品和空气污染会损害我们皮肤的上皮，肺和胃肠系统。上皮屏障破坏导致微生物组的生物多样性减少和机会性病原体定植的发展。一旦与免疫系统相互作用，引发局部和全身炎症。对环境之间的相互作用有了更深入的理解，微生物组和免疫系统提供数据，以协助法律规范有毒物质的使用，实现无毒替代品，并减轻这些环境挑战，这对于促进和谐健康的全球环境至关重要。
结果：已经提出了一些假设，试图解释观察到的这些疾病的增加，如“卫生假说”，\'老朋友\',和“生物多样性和菌群失调”。最近引入的“上皮屏障理论”包含了这些以前的假设，并表明清洁剂中的有毒物质，洗衣和洗碗机洗涤剂，洗发水,牙膏,以及微塑料，包装食品和空气污染会损害我们皮肤的上皮，肺和胃肠系统。上皮屏障破坏导致微生物组的生物多样性减少和机会性病原体定植的发展。一旦与免疫系统相互作用，引发局部和全身炎症。对环境之间的相互作用有了更深入的理解，微生物组和免疫系统提供数据，以协助法律规范有毒物质的使用，实现无毒替代品，并减轻这些环境挑战，这对于促进和谐健康的全球环境至关重要。
