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Abstract：
Zinc tungstate is a semiconductor known for its favorable photocatalytic, photoluminescence, and scintillation properties, coupled with its relatively low cost, reduced toxicity, and high stability in biological and catalytic environments. In particular, zinc tungstate evinces scintillation properties, namely the ability to emit visible light upon absorption of energetic radiation such as x rays, which has led to applications not only as radiation detectors but also for biomedical applications involving the delivery of optical light to deep tissue, such as photodynamic therapy and optogenetics. Here, we report on the synthesis of zinc tungstate nanorods generated via an optimized but facile method, which allows for synthetic control over the aspect ratio of the as-synthesized anisotropic motifs via rational variation of the solution pH. We investigate the effect of aspect ratio on their resulting photoluminescent and radioluminescent properties. We further demonstrate the potential of these zinc tungstate nanorods for biomedical applications, such as photodynamic therapy for cancer treatment, by analyzing their toxicological profile within cell lines and neurons.
摘要：
钨酸锌是一种以其有利的光催化作用而闻名的半导体，光致发光，和闪烁特性，加上其相对较低的成本，降低毒性，在生物和催化环境中的高稳定性。特别是,钨酸锌表现出闪烁特性，即吸收高能辐射如x射线时发出可见光的能力，这不仅导致了辐射探测器的应用，还导致了生物医学应用，包括将光学光传递到深层组织，如光动力疗法和光遗传学。这里,我们报告了通过优化但简便的方法合成钨酸锌纳米棒，这允许通过溶液pH的合理变化对合成后的各向异性基序的纵横比进行综合控制。我们研究了纵横比对其所得光致发光和放射性发光特性的影响。我们进一步证明了这些钨酸锌纳米棒在生物医学应用中的潜力，例如用于癌症治疗的光动力疗法，通过分析它们在细胞系和神经元中的毒理学特征。
