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Abstract：
Hyalinizing clear cell carcinomas (HCCCs) are infrequent, malignant tumors characterized by their low-grade nature. They typically originate from minor salivary glands. However, these tumors can potentially emerge in any location with minor salivary glands, including the nasopharynx. This report presents two cases of HCCC in females aged 61 and 72 years, with both tumors approximately 4 cm in size. In the first case, a 72-year-old female presented with recurrent bilateral epistaxis. Imaging studies revealed a nasopharyngeal mass, surgically excised, and histopathological analysis confirmed HCCC. Postoperatively, the patient received combined chemotherapy and radiotherapy, achieving a recurrence-free status 2.5 years later. The second case involves a 61-year-old female with a two-year history of bloody nasal discharge. Imaging studies identified a nasopharyngeal lesion, surgically removed, and histopathological examination confirmed HCCC. This patient underwent radiotherapy followed by combination chemotherapy with paclitaxel and carboplatin, displaying no signs of recurrence upon reevaluation after 10 months. These cases highlight the successful management of HCCC through a comprehensive, multimodal approach, integrating surgical intervention and adjuvant therapy. The favorable outcomes emphasize the significance of a thorough treatment strategy for HCCC in the nasopharynx, providing valuable insights for clinicians. Further studies are essential to enhance our understanding of this rare entity and refine treatment protocols for optimized patient outcomes.
摘要：
透明细胞癌（HCCCs）很少见，以低度性质为特征的恶性肿瘤。它们通常起源于小唾液腺。然而,这些肿瘤可能出现在任何有小唾液腺的地方，包括鼻咽.本报告介绍了两例61岁和72岁女性的HCCC病例，两个肿瘤的大小约为4厘米。在第一种情况下,一名72岁女性患者反复出现双侧鼻出血.影像学检查显示有鼻咽肿块,手术切除,组织病理学分析证实HCCC。术后,患者接受了联合化疗和放疗，2.5年后达到无复发状态。第二例涉及一名61岁的女性，有两年的流鼻血史。影像学检查发现鼻咽病变,手术切除,组织病理学检查证实为HCCC。该患者接受了放疗，然后是紫杉醇和卡铂的联合化疗，10个月后再评估未显示复发迹象。这些案例凸显了HCCC的成功管理，多模式方法，综合手术干预和辅助治疗。有利的结果强调了鼻咽部HCCC彻底治疗策略的重要性，为临床医生提供有价值的见解。进一步的研究对于增强我们对这种罕见实体的理解和完善治疗方案以优化患者预后至关重要。
