PDF(Pubmed)
Abstract：
The Shroom (Shrm) family of actin-binding proteins has a unique and highly conserved Apx/Shrm Domain 2 (ASD2) motif. Shroom protein directs the subcellular localization of Rho-associated kinase (ROCK), which remodels the actomyosin cytoskeleton and changes cellular morphology via its ability to phosphorylate and activate non-muscle myosin II. Therefore, the Shrm-ROCK complex is critical for the cellular shape and the development of many tissues, including the neural tube, eye, intestines, heart, and vasculature system. Importantly, the structure and expression of Shrm proteins are also associated with neural tube defects, chronic kidney disease, metastasis of carcinoma, and X-link mental retardation. Therefore, a better understanding of Shrm-mediated signaling transduction pathways is essential for the development of new therapeutic strategies to minimize damage resulting in abnormal Shrm proteins. This paper provides a comprehensive overview of the various Shrm proteins and their roles in morphogenesis and disease.
摘要：
肌动蛋白结合蛋白的Shroom(Shrm)家族具有独特且高度保守的Apx/Shrm结构域2(ASD2)基序。shroom蛋白指导Rho相关激酶（ROCK）的亚细胞定位，通过磷酸化和激活非肌肉肌球蛋白II的能力重塑肌动球蛋白细胞骨架并改变细胞形态。因此,Shrm-ROCK复合体对细胞形状和许多组织的发育至关重要，包括神经管,眼睛,肠子,心,和脉管系统。重要的是,Shrm蛋白的结构和表达也与神经管缺陷有关,慢性肾病,癌转移，和X-link智力迟钝.因此,更好地了解Shrm介导的信号转导通路对于开发新的治疗策略以最大程度地减少导致异常Shrm蛋白的损伤至关重要.本文对各种Shrm蛋白及其在形态发生和疾病中的作用进行了全面综述。
