Abstract：
As a biothiol, cysteine (Cys) is essential to both physiological and pathological processes and has been associated with many diseases, including neurological disorders, rheumatoid arthritis, and renal dysfunction. Therefore, the development of a high-performance probe for detecting Cys levels can help prevent and diagnose disease. In this study, a ratiometric fluorescent probe based on a novel fluorophore was developed for detecting Cys, and it showed high specificity and a rapid response time toward Cys. This probe demonstrates excellent biocompatibility and has been utilized effectively for the imaging of Cys in living cells.
摘要：
作为生物硫醇，半胱氨酸(Cys)在生理和病理过程中都是必不可少的，并且与许多疾病有关。包括神经系统疾病，类风湿性关节炎,肾功能不全.因此,用于检测Cys水平的高性能探针的开发可以帮助预防和诊断疾病。在这项研究中,开发了一种基于新型荧光团的比率荧光探针，用于检测Cys，它显示出高特异性和对Cys的快速响应时间。该探针显示出优异的生物相容性,并且已经有效地用于活细胞中的Cys的成像。
