Abstract：
OBJECTIVE: Previous studies have shown that skin autofluorescence (SAF), measured with an advanced glycation end product (AGE) reader, estimates the accumulation of AGEs in tissues. SAF is predictive of incident type 2 diabetes, cardiovascular disease (CVD), and CV mortality in the general population. Studies in diabetic mice have shown that activation of the receptor for AGEs in hematopoietic progenitor cells increases blood neutrophils and monocytes, impairing atherosclerosis regression. We asked whether SAF is associated with blood neutrophil and monocyte counts in the general population, and whether this was moderated by prediabetes, diabetes, and sex.
METHODS: We examined the associations between SAF and blood neutrophil/monocyte counts in participants of the Lifelines cohort (n = 58,923: n = 24,382 men, and n = 34,541 women), a prospective population-based cohort from the North of the Netherlands, employing multivariable regression analyses.
RESULTS: SAF positively associated with blood neutrophil and monocyte counts in the whole cohort. The positive association between SAF and monocyte, but not neutrophil, counts was moderated by prediabetes and diabetes. Positive associations between SAF and blood neutrophil and monocyte counts were moderated by male sex. Moreover, three-way interaction analyses revealed that the positive associations between SAF and neutrophil and monocyte counts were moderated by prediabetes, but not diabetes, in male sex.
CONCLUSIONS: SAF is positively associated with blood neutrophil and monocyte counts in the general population, especially in men with prediabetes. This may contribute to the increased CV risk in men with prediabetes.
METHODS: We examined the associations between SAF and blood neutrophil/monocyte counts in participants of the Lifelines cohort (n = 58,923: n = 24,382 men, and n = 34,541 women), a prospective population-based cohort from the North of the Netherlands, employing multivariable regression analyses.
RESULTS: SAF positively associated with blood neutrophil and monocyte counts in the whole cohort. The positive association between SAF and monocyte, but not neutrophil, counts was moderated by prediabetes and diabetes. Positive associations between SAF and blood neutrophil and monocyte counts were moderated by male sex. Moreover, three-way interaction analyses revealed that the positive associations between SAF and neutrophil and monocyte counts were moderated by prediabetes, but not diabetes, in male sex.
CONCLUSIONS: SAF is positively associated with blood neutrophil and monocyte counts in the general population, especially in men with prediabetes. This may contribute to the increased CV risk in men with prediabetes.
摘要：
目的：以前的研究表明，皮肤自发荧光（SAF），用糖基化终产物(AGE)读数仪测量，估计AGE在组织中的积累。SAF可以预测2型糖尿病的发生，心血管疾病（CVD），和一般人群的CV死亡率。在糖尿病小鼠中的研究表明，造血祖细胞中AGEs受体的激活会增加血液中性粒细胞和单核细胞，损害动脉粥样硬化消退。我们询问SAF是否与普通人群的血液中性粒细胞和单核细胞计数有关，这是否由糖尿病前期缓解，糖尿病,和性爱。
方法：我们检查了生命队列参与者的SAF与血液中性粒细胞/单核细胞计数之间的关联（n=58,923：n=24,382名男性，n=34,541名女性)，来自荷兰北部的前瞻性基于人口的队列，采用多元回归分析。
结果：在整个队列中，SAF与血液中性粒细胞和单核细胞计数呈正相关。SAF和单核细胞之间的正相关，但不是中性粒细胞,计数由糖尿病前期和糖尿病调节。SAF与血液中性粒细胞和单核细胞计数之间的正相关由男性调节。此外，三因素相互作用分析显示，SAF与中性粒细胞和单核细胞计数之间的正相关由糖尿病前期调节，但不是糖尿病，在男性中。
结论：在一般人群中，SAF与血液中性粒细胞和单核细胞计数呈正相关，尤其是在男性糖尿病前期。这可能导致糖尿病前期男性的CV风险增加。
方法：我们检查了生命队列参与者的SAF与血液中性粒细胞/单核细胞计数之间的关联（n=58,923：n=24,382名男性，n=34,541名女性)，来自荷兰北部的前瞻性基于人口的队列，采用多元回归分析。
结果：在整个队列中，SAF与血液中性粒细胞和单核细胞计数呈正相关。SAF和单核细胞之间的正相关，但不是中性粒细胞,计数由糖尿病前期和糖尿病调节。SAF与血液中性粒细胞和单核细胞计数之间的正相关由男性调节。此外，三因素相互作用分析显示，SAF与中性粒细胞和单核细胞计数之间的正相关由糖尿病前期调节，但不是糖尿病，在男性中。
结论：在一般人群中，SAF与血液中性粒细胞和单核细胞计数呈正相关，尤其是在男性糖尿病前期。这可能导致糖尿病前期男性的CV风险增加。
