Abstract：
Members of the myosin superfamily of molecular motors are large mechanochemical ATPases that are implicated in an ever-expanding array of cellular functions. This review focuses on mammalian nonmuscle myosin-2 (NM2) paralogs, ubiquitous members of the myosin-2 family of filament-forming motors. Through the conversion of chemical energy into mechanical work, NM2 paralogs remodel and shape cells and tissues. This process is tightly controlled in time and space by numerous synergetic regulation mechanisms to meet cellular demands. We review how recent advances in structural biology together with elegant biophysical and cell biological approaches have contributed to our understanding of the shared and unique mechanisms of NM2 paralogs as they relate to their kinetics, regulation, assembly, and cellular function.
摘要：
分子马达的肌球蛋白超家族的成员是大型机械化学ATP酶，它们与不断扩展的细胞功能有关。这篇综述集中在哺乳动物非肌肉肌球蛋白-2（NM2）旁系同源物，肌球蛋白-2家族的细丝形成马达的普遍存在的成员。通过化学能转化为机械功，NM2旁系同源物重塑并塑造细胞和组织。此过程在时间和空间上受到许多协同调节机制的严格控制，以满足细胞需求。我们回顾了结构生物学的最新进展以及优雅的生物物理和细胞生物学方法如何有助于我们对NM2旁系同源物的共同和独特机制的理解，因为它们与它们的动力学有关。regulation,装配,和细胞功能。
