PDF(Pubmed)
Abstract：
We assessed the short-term effects of switching from intravitreal aflibercept (IVA) to intravitreal faricimab (IVF) on ocular blood flow in patients with treatment-resistant diabetic macular edema (DME). The medical records of 15 patients with DME who had received IVA injection ≥ 3 months before were retrospectively reviewed. The best-corrected visual acuity, central macular thickness (CMT) on optical coherence tomography, and mean blur rate (MBR) of all disc areas on laser speckle flowgraphy were measured before, 1 week after, and 4 weeks after IVA and IVF, respectively. The changes in visual acuity showed no significant difference after switching from IVA to IVF (P = 0.732). The mean CMT decreased significantly during the follow-up period (both P < 0.001). MBR showed no significant difference during the follow-up period (P = 0.26). However, it decreased significantly 4 weeks after IVF (P = 0.01) compared with the baseline value, but not 4 weeks after IVA (P = 0.074). A significant association was observed between decreased MBR and decreased CMT in patients who received IVF (correlation coefficient: 0.501, P = 0.005) but not in those who received IVA (P = 0.735). Thus, IVF maintained ocular blood flow reduction, although no significant differences in visual acuity and CMT changes were observed compared to IVA.
摘要：
我们评估了从玻璃体内阿柏西普（IVA）转换为玻璃体内法利克单抗（IVF）对难治性糖尿病性黄斑水肿（DME）患者眼血流的短期影响。回顾性回顾了15例DME患者的病历，这些患者在3个月前接受了IVA注射。最好的矫正视力，光学相干断层扫描的中央黄斑厚度（CMT），和平均模糊率（MBR）的所有区域的激光散斑流前测量，1周后,IVA和IVF后4周，分别。从IVA切换到IVF后，视力的变化没有显着差异（P=0.732）。平均CMT在随访期间显著下降(均P<0.001)。随访期间MBR差异无统计学意义(P=0.26)。然而,与基线值相比，IVF后4周显着降低（P=0.01），但不是IVA后4周（P=0.074）。在接受IVF的患者中，MBR降低和CMT降低之间存在显着相关性（相关系数：0.501，P=0.005），但在接受IVA的患者中没有相关性（P=0.735）。因此，IVF维持眼血流减少，尽管与IVA相比，视力和CMT变化没有显着差异。
